Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1084814..1085340 Replicon chromosome
Accession NZ_CP079767
Organism Escherichia coli strain SF10

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KX927_RS07670 Protein ID WP_000323025.1
Coordinates 1085053..1085340 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KX927_RS07665 Protein ID WP_000534858.1
Coordinates 1084814..1085053 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX927_RS07615 (1079909) 1079909..1080064 - 156 WP_000379575.1 DUF1391 family protein -
KX927_RS07620 (1080231) 1080231..1080638 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
KX927_RS07625 (1080722) 1080722..1080952 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
KX927_RS07630 (1080936) 1080936..1081127 + 192 Protein_1083 protein YdfX -
KX927_RS07635 (1081104) 1081104..1081226 + 123 Protein_1084 hypothetical protein -
KX927_RS07640 (1081226) 1081226..1081575 + 350 Protein_1085 hypothetical protein -
KX927_RS07645 (1082220) 1082220..1083242 + 1023 Protein_1086 ISNCY family transposase -
KX927_RS07650 (1083363) 1083363..1083512 + 150 WP_011443592.1 protein YdfW -
KX927_RS07655 (1083949) 1083949..1084281 - 333 WP_001301033.1 FlxA-like family protein -
KX927_RS07660 (1084484) 1084484..1084789 - 306 WP_001326990.1 protein YdfV -
KX927_RS07665 (1084814) 1084814..1085053 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KX927_RS07670 (1085053) 1085053..1085340 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KX927_RS07675 (1085412) 1085412..1085567 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KX927_RS07680 (1085737) 1085737..1086411 + 675 Protein_1093 DUF968 domain-containing protein -
KX927_RS07685 (1086425) 1086425..1087177 + 753 WP_001047135.1 antitermination protein -
KX927_RS07690 (1087455) 1087455..1087544 - 90 WP_120795389.1 hypothetical protein -
KX927_RS07695 (1087599) 1087599..1087811 - 213 WP_000087756.1 cold shock-like protein CspF -
KX927_RS07700 (1088112) 1088112..1088327 + 216 WP_000066484.1 cold shock-like protein CspB -
KX927_RS07705 (1088691) 1088691..1088861 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KX927_RS07710 (1089081) 1089081..1089296 + 216 WP_000839590.1 phage lysis protein EssD -
KX927_RS07715 (1089301) 1089301..1089612 + 312 WP_000189916.1 YdfR family protein -
KX927_RS07720 (1089609) 1089609..1090142 + 534 WP_001092971.1 lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1067917..1100181 32264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T209975 WP_000323025.1 NZ_CP079767:1085053-1085340 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T209975 NZ_CP104358:310524-310892 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT209975 WP_000534858.1 NZ_CP079767:1084814-1085053 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT209975 NZ_CP104358:310306-310527 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References