209975

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1084814..1085340 Replicon chromosome
Accession NZ_CP079767
Organism Escherichia coli strain SF10

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KX927_RS07670 Protein ID WP_000323025.1
Coordinates 1085053..1085340 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KX927_RS07665 Protein ID WP_000534858.1
Coordinates 1084814..1085053 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX927_RS07615 (1079909) 1079909..1080064 - 156 WP_000379575.1 DUF1391 family protein -
KX927_RS07620 (1080231) 1080231..1080638 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
KX927_RS07625 (1080722) 1080722..1080952 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
KX927_RS07630 (1080936) 1080936..1081127 + 192 Protein_1083 protein YdfX -
KX927_RS07635 (1081104) 1081104..1081226 + 123 Protein_1084 hypothetical protein -
KX927_RS07640 (1081226) 1081226..1081575 + 350 Protein_1085 hypothetical protein -
KX927_RS07645 (1082220) 1082220..1083242 + 1023 Protein_1086 ISNCY family transposase -
KX927_RS07650 (1083363) 1083363..1083512 + 150 WP_011443592.1 protein YdfW -
KX927_RS07655 (1083949) 1083949..1084281 - 333 WP_001301033.1 FlxA-like family protein -
KX927_RS07660 (1084484) 1084484..1084789 - 306 WP_001326990.1 protein YdfV -
KX927_RS07665 (1084814) 1084814..1085053 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KX927_RS07670 (1085053) 1085053..1085340 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KX927_RS07675 (1085412) 1085412..1085567 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KX927_RS07680 (1085737) 1085737..1086411 + 675 Protein_1093 DUF968 domain-containing protein -
KX927_RS07685 (1086425) 1086425..1087177 + 753 WP_001047135.1 antitermination protein -
KX927_RS07690 (1087455) 1087455..1087544 - 90 WP_120795389.1 hypothetical protein -
KX927_RS07695 (1087599) 1087599..1087811 - 213 WP_000087756.1 cold shock-like protein CspF -
KX927_RS07700 (1088112) 1088112..1088327 + 216 WP_000066484.1 cold shock-like protein CspB -
KX927_RS07705 (1088691) 1088691..1088861 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KX927_RS07710 (1089081) 1089081..1089296 + 216 WP_000839590.1 phage lysis protein EssD -
KX927_RS07715 (1089301) 1089301..1089612 + 312 WP_000189916.1 YdfR family protein -
KX927_RS07720 (1089609) 1089609..1090142 + 534 WP_001092971.1 lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1067917..1100181 32264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T209975 WP_000323025.1 NZ_CP079767:1085053-1085340 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T209975 NZ_CP104358:310524-310892 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT209975 WP_000534858.1 NZ_CP079767:1084814-1085053 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT209975 NZ_CP104358:310306-310527 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References