264784

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2096329..2096855 Replicon chromosome
Accession NZ_CP111008
Organism Escherichia coli strain J53-p130

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ORI87_RS10210 Protein ID WP_000323025.1
Coordinates 2096568..2096855 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ORI87_RS10205 Protein ID WP_000534858.1
Coordinates 2096329..2096568 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI87_RS10145 (2091356) 2091356..2092123 - 768 Protein_1980 exonuclease -
ORI87_RS10150 (2092216) 2092216..2092407 - 192 WP_001083297.1 lysis protein YdfD -
ORI87_RS10155 (2092404) 2092404..2092592 - 189 WP_000854559.1 cell division inhibition protein DicB -
ORI87_RS10160 (2093160) 2093160..2093378 - 219 WP_001171942.1 protein YdfC -
ORI87_RS10165 (2093408) 2093408..2093536 - 129 WP_000344964.1 protein YdfB -
ORI87_RS10170 (2093538) 2093538..2093693 - 156 WP_000379575.1 DUF1391 family protein -
ORI87_RS10175 (2093860) 2093860..2094267 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
ORI87_RS10180 (2094351) 2094351..2094581 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
ORI87_RS10185 (2094565) 2094565..2094843 + 279 Protein_1988 hypothetical protein -
ORI87_RS10190 (2094878) 2094878..2095027 + 150 WP_011443592.1 protein YdfW -
ORI87_RS10195 (2095464) 2095464..2095796 - 333 WP_001301033.1 FlxA-like family protein -
ORI87_RS10200 (2095999) 2095999..2096304 - 306 WP_001326990.1 protein YdfV -
ORI87_RS10205 (2096329) 2096329..2096568 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ORI87_RS10210 (2096568) 2096568..2096855 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ORI87_RS10215 (2096927) 2096927..2097082 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ORI87_RS10220 (2097299) 2097299..2097550 + 252 WP_000980994.1 protein Rem -
ORI87_RS10225 (2097617) 2097617..2097895 + 279 WP_012304870.1 hypothetical protein -
ORI87_RS10230 (2097897) 2097897..2098946 + 1050 WP_001265198.1 DUF968 domain-containing protein -
ORI87_RS10235 (2098960) 2098960..2099712 + 753 WP_001047135.1 antitermination protein -
ORI87_RS10240 (2099990) 2099990..2100079 - 90 WP_120795389.1 hypothetical protein -
ORI87_RS10245 (2100134) 2100134..2100346 - 213 WP_000087756.1 cold shock-like protein CspF -
ORI87_RS10250 (2100647) 2100647..2100862 + 216 WP_000066484.1 cold shock-like protein CspB -
ORI87_RS10255 (2101226) 2101226..2101396 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
ORI87_RS10260 (2101616) 2101616..2101831 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2077738..2111199 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T264784 WP_000323025.1 NZ_CP111008:2096568-2096855 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT264784 WP_000534858.1 NZ_CP111008:2096329-2096568 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References