205746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4099135..4099661 Replicon chromosome
Accession NZ_CP076470
Organism Escherichia coli strain DH5a

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KN807_RS19780 Protein ID WP_000323025.1
Coordinates 4099374..4099661 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KN807_RS19775 Protein ID WP_000534858.1
Coordinates 4099135..4099374 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KN807_RS19720 (4094162) 4094162..4094929 - 768 Protein_3851 exonuclease -
KN807_RS19725 (4095022) 4095022..4095213 - 192 WP_001083297.1 lysis protein YdfD -
KN807_RS19730 (4095210) 4095210..4095398 - 189 WP_000854559.1 cell division inhibition protein DicB -
KN807_RS19735 (4095966) 4095966..4096184 - 219 WP_001171942.1 protein YdfC -
KN807_RS22310 (4096214) 4096214..4096342 - 129 WP_000344964.1 protein YdfB -
KN807_RS19740 (4096344) 4096344..4096499 - 156 WP_000379575.1 DUF1391 family protein -
KN807_RS19745 (4096666) 4096666..4097073 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
KN807_RS19750 (4097157) 4097157..4097387 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
KN807_RS19755 (4097371) 4097371..4097649 + 279 Protein_3859 protein YdfX -
KN807_RS19760 (4097684) 4097684..4097833 + 150 WP_011443592.1 protein YdfW -
KN807_RS19765 (4098270) 4098270..4098602 - 333 WP_001301033.1 FlxA-like family protein -
KN807_RS19770 (4098805) 4098805..4099110 - 306 WP_001326990.1 protein YdfV -
KN807_RS19775 (4099135) 4099135..4099374 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KN807_RS19780 (4099374) 4099374..4099661 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KN807_RS19785 (4099733) 4099733..4099888 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KN807_RS19790 (4100105) 4100105..4100356 + 252 WP_000980994.1 protein Rem -
KN807_RS19795 (4100423) 4100423..4100701 + 279 WP_012304870.1 hypothetical protein -
KN807_RS19800 (4100703) 4100703..4101752 + 1050 WP_001265198.1 DUF968 domain-containing protein -
KN807_RS19805 (4101766) 4101766..4102518 + 753 WP_001047135.1 antitermination protein -
KN807_RS19810 (4102796) 4102796..4102885 - 90 WP_120795389.1 hypothetical protein -
KN807_RS19815 (4102940) 4102940..4103152 - 213 WP_000087756.1 cold shock-like protein CspF -
KN807_RS19820 (4103453) 4103453..4103668 + 216 WP_000066484.1 cold shock-like protein CspB -
KN807_RS19825 (4104032) 4104032..4104202 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KN807_RS19830 (4104422) 4104422..4104637 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4079180..4114005 34825


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T205746 WP_000323025.1 NZ_CP076470:4099374-4099661 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T205746 NZ_CP101866:3387167-3387709 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT205746 WP_000534858.1 NZ_CP076470:4099135-4099374 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT205746 NZ_CP101866:3386872-3387183 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References