266961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3470949..3471475 Replicon chromosome
Accession NZ_CP114893
Organism Escherichia coli strain CM13

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag O6R07_RS16940 Protein ID WP_000323025.1
Coordinates 3471188..3471475 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag O6R07_RS16935 Protein ID WP_000534858.1
Coordinates 3470949..3471188 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6R07_RS16875 (3465976) 3465976..3466743 - 768 Protein_3279 exonuclease -
O6R07_RS16880 (3466836) 3466836..3467027 - 192 WP_001083297.1 lysis protein YdfD -
O6R07_RS16885 (3467024) 3467024..3467212 - 189 WP_000854559.1 cell division inhibition protein DicB -
O6R07_RS16890 (3467780) 3467780..3467998 - 219 WP_001171942.1 protein YdfC -
O6R07_RS16895 (3468028) 3468028..3468156 - 129 WP_000344964.1 protein YdfB -
O6R07_RS16900 (3468158) 3468158..3468313 - 156 WP_000379575.1 DUF1391 family protein -
O6R07_RS16905 (3468480) 3468480..3468887 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
O6R07_RS16910 (3468971) 3468971..3469201 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
O6R07_RS16915 (3469185) 3469185..3469463 + 279 Protein_3287 protein YdfX -
O6R07_RS16920 (3469498) 3469498..3469647 + 150 WP_011443592.1 protein YdfW -
O6R07_RS16925 (3470084) 3470084..3470416 - 333 WP_001301033.1 FlxA-like family protein -
O6R07_RS16930 (3470619) 3470619..3470924 - 306 WP_001326990.1 protein YdfV -
O6R07_RS16935 (3470949) 3470949..3471188 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
O6R07_RS16940 (3471188) 3471188..3471475 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
O6R07_RS16945 (3471547) 3471547..3471702 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
O6R07_RS16950 (3471919) 3471919..3472170 + 252 WP_000980994.1 protein Rem -
O6R07_RS16955 (3472237) 3472237..3472515 + 279 WP_012304870.1 hypothetical protein -
O6R07_RS16960 (3472517) 3472517..3473566 + 1050 WP_001265198.1 DUF968 domain-containing protein -
O6R07_RS16965 (3473580) 3473580..3474332 + 753 WP_001047135.1 antitermination protein -
O6R07_RS16970 (3474610) 3474610..3474699 - 90 WP_120795389.1 hypothetical protein -
O6R07_RS16975 (3474754) 3474754..3474966 - 213 WP_000087756.1 cold shock-like protein CspF -
O6R07_RS16980 (3475267) 3475267..3475482 + 216 WP_000066484.1 cold shock-like protein CspB -
O6R07_RS16985 (3475846) 3475846..3476016 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
O6R07_RS16990 (3476236) 3476236..3476451 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3451022..3485819 34797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T266961 WP_000323025.1 NZ_CP114893:3471188-3471475 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT266961 WP_000534858.1 NZ_CP114893:3470949-3471188 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References