257599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2239698..2240224 Replicon chromosome
Accession NZ_CP104326
Organism Escherichia coli strain THB42-F1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N0470_RS10845 Protein ID WP_000323025.1
Coordinates 2239937..2240224 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N0470_RS10840 Protein ID WP_000534858.1
Coordinates 2239698..2239937 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0470_RS10780 (2234725) 2234725..2235492 - 768 Protein_2104 exonuclease -
N0470_RS10785 (2235585) 2235585..2235776 - 192 WP_001083297.1 lysis protein YdfD -
N0470_RS10790 (2235773) 2235773..2235961 - 189 WP_000854559.1 cell division inhibition protein DicB -
N0470_RS10795 (2236529) 2236529..2236747 - 219 WP_001171942.1 protein YdfC -
N0470_RS10800 (2236777) 2236777..2236905 - 129 WP_000344964.1 protein YdfB -
N0470_RS10805 (2236907) 2236907..2237062 - 156 WP_000379575.1 DUF1391 family protein -
N0470_RS10810 (2237229) 2237229..2237636 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
N0470_RS10815 (2237720) 2237720..2237950 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
N0470_RS10820 (2237934) 2237934..2238212 + 279 Protein_2112 hypothetical protein -
N0470_RS10825 (2238247) 2238247..2238396 + 150 WP_011443592.1 protein YdfW -
N0470_RS10830 (2238833) 2238833..2239165 - 333 WP_001301033.1 FlxA-like family protein -
N0470_RS10835 (2239368) 2239368..2239673 - 306 WP_001326990.1 protein YdfV -
N0470_RS10840 (2239698) 2239698..2239937 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N0470_RS10845 (2239937) 2239937..2240224 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
N0470_RS10850 (2240296) 2240296..2240451 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
N0470_RS10855 (2240668) 2240668..2240919 + 252 WP_000980994.1 protein Rem -
N0470_RS10860 (2240986) 2240986..2241264 + 279 WP_012304870.1 hypothetical protein -
N0470_RS10865 (2241266) 2241266..2242315 + 1050 WP_001265198.1 DUF968 domain-containing protein -
N0470_RS10870 (2242329) 2242329..2243081 + 753 WP_001047135.1 antitermination protein -
N0470_RS10875 (2243359) 2243359..2243448 - 90 WP_120795389.1 hypothetical protein -
N0470_RS10880 (2243503) 2243503..2243715 - 213 WP_000087756.1 cold shock-like protein CspF -
N0470_RS10885 (2244016) 2244016..2244231 + 216 WP_000066484.1 cold shock-like protein CspB -
N0470_RS10890 (2244595) 2244595..2244765 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
N0470_RS10895 (2244985) 2244985..2245200 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2221107..2254568 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T257599 WP_000323025.1 NZ_CP104326:2239937-2240224 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT257599 WP_000534858.1 NZ_CP104326:2239698-2239937 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References