204324

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2242625..2243151 Replicon chromosome
Accession NZ_CP075722
Organism Escherichia coli strain CPE35

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KKZ10_RS10865 Protein ID WP_000323025.1
Coordinates 2242864..2243151 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KKZ10_RS10860 Protein ID WP_000534858.1
Coordinates 2242625..2242864 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ10_RS10820 (2238284) 2238284..2238502 - 219 WP_001171942.1 protein YdfC -
KKZ10_RS10825 (2238532) 2238532..2238660 - 129 WP_000344964.1 protein YdfB -
KKZ10_RS10830 (2238662) 2238662..2238817 - 156 WP_000379575.1 DUF1391 family protein -
KKZ10_RS10835 (2238954) 2238954..2239375 + 422 Protein_2115 hypothetical protein -
KKZ10_RS10840 (2240031) 2240031..2241053 + 1023 Protein_2116 ISNCY family transposase -
KKZ10_RS10845 (2241174) 2241174..2241323 + 150 WP_011443592.1 protein YdfW -
KKZ10_RS10850 (2241760) 2241760..2242092 - 333 WP_001301033.1 FlxA-like family protein -
KKZ10_RS10855 (2242295) 2242295..2242600 - 306 WP_001326990.1 protein YdfV -
KKZ10_RS10860 (2242625) 2242625..2242864 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KKZ10_RS10865 (2242864) 2242864..2243151 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KKZ10_RS10870 (2243223) 2243223..2243378 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KKZ10_RS10875 (2243595) 2243595..2243846 + 252 WP_000980994.1 protein Rem -
KKZ10_RS10880 (2243913) 2243913..2244191 + 279 WP_012304870.1 hypothetical protein -
KKZ10_RS10885 (2244193) 2244193..2245242 + 1050 WP_001265199.1 DUF968 domain-containing protein -
KKZ10_RS10890 (2245256) 2245256..2246008 + 753 WP_001047135.1 antitermination protein -
KKZ10_RS10895 (2246286) 2246286..2246375 - 90 WP_120795389.1 hypothetical protein -
KKZ10_RS10900 (2246430) 2246430..2246642 - 213 WP_000087756.1 cold shock-like protein CspF -
KKZ10_RS10905 (2246943) 2246943..2247158 + 216 WP_000066484.1 cold shock-like protein CspB -
KKZ10_RS10910 (2247522) 2247522..2247692 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KKZ10_RS10915 (2247912) 2247912..2248127 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2222554..2259693 37139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T204324 WP_000323025.1 NZ_CP075722:2242864-2243151 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T204324 NZ_CP100698:3618181-3618438 [Salmonella enterica subsp. enterica serovar Agona]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGTATAACCACCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCACAGGGGTGTA
TTGTGCTAATGGCGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACGGGTGGTTAAGGGGTTG
AAGGATGTACTGGTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT204324 WP_000534858.1 NZ_CP075722:2242625-2242864 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT204324 NZ_CP100698:c3618402-3618024 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References