190295

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 275664..276190 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JSW75_RS01350 Protein ID WP_000323025.1
Coordinates 275664..275951 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JSW75_RS01355 Protein ID WP_000534858.1
Coordinates 275951..276190 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS01300 (270688) 270688..270903 - 216 WP_000839590.1 phage lysis protein EssD -
JSW75_RS01305 (271123) 271123..271293 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
JSW75_RS01310 (271657) 271657..271872 - 216 WP_000066484.1 cold shock-like protein CspB -
JSW75_RS01315 (272173) 272173..272385 + 213 WP_000087756.1 cold shock-like protein CspF -
JSW75_RS01320 (272440) 272440..272529 + 90 WP_120795389.1 hypothetical protein -
JSW75_RS01325 (272807) 272807..273559 - 753 WP_001047135.1 antitermination protein -
JSW75_RS01330 (273573) 273573..274622 - 1050 WP_001265198.1 DUF968 domain-containing protein -
JSW75_RS01335 (274624) 274624..274902 - 279 WP_012304870.1 hypothetical protein -
JSW75_RS01340 (274969) 274969..275220 - 252 WP_000980994.1 protein Rem -
JSW75_RS01345 (275437) 275437..275592 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JSW75_RS01350 (275664) 275664..275951 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JSW75_RS01355 (275951) 275951..276190 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JSW75_RS01360 (276215) 276215..276520 + 306 WP_001326990.1 protein YdfV -
JSW75_RS01365 (276723) 276723..277055 + 333 WP_001301033.1 FlxA-like family protein -
JSW75_RS01370 (277492) 277492..277641 - 150 WP_011443592.1 protein YdfW -
JSW75_RS01375 (277676) 277676..277954 - 279 Protein_274 hypothetical protein -
JSW75_RS01380 (277938) 277938..278168 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
JSW75_RS01385 (278252) 278252..278659 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
JSW75_RS01390 (278826) 278826..278981 + 156 WP_000379575.1 DUF1391 family protein -
JSW75_RS01395 (279141) 279141..279359 + 219 WP_001171942.1 protein YdfC -
JSW75_RS01400 (279927) 279927..280115 + 189 WP_000854559.1 cell division inhibition protein DicB -
JSW75_RS01405 (280112) 280112..280303 + 192 WP_001083297.1 lysis protein YdfD -
JSW75_RS01410 (280396) 280396..281163 + 768 Protein_281 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 261320..294781 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T190295 WP_000323025.1 NZ_CP069386:c275951-275664 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T190295 NZ_CP091235:598093-598209 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT190295 WP_000534858.1 NZ_CP069386:c276190-275951 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT190295 NZ_CP091235:c598325-598120 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References