Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2249965..2250491 Replicon chromosome
Accession NZ_CP047594
Organism Escherichia coli strain LD27-1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag GUU88_RS10955 Protein ID WP_000323025.1
Coordinates 2249965..2250252 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag GUU88_RS10960 Protein ID WP_000534858.1
Coordinates 2250252..2250491 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU88_RS10910 2245163..2245696 - 534 WP_001092971.1 lysozyme -
GUU88_RS10915 2245693..2246004 - 312 WP_000189916.1 YdfR family protein -
GUU88_RS10920 2246009..2246224 - 216 WP_000839590.1 phage lysis protein EssD -
GUU88_RS10925 2246978..2247193 - 216 WP_000066484.1 cold shock-like protein CspB -
GUU88_RS10930 2247494..2247706 + 213 WP_000087756.1 cold shock-like protein CspF -
GUU88_RS10935 2247761..2247850 + 90 WP_120795389.1 hypothetical protein -
GUU88_RS10940 2248128..2248880 - 753 WP_001047135.1 antitermination protein -
GUU88_RS10945 2248894..2249568 - 675 Protein_2137 DUF968 domain-containing protein -
GUU88_RS10950 2249738..2249893 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
GUU88_RS10955 2249965..2250252 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
GUU88_RS10960 2250252..2250491 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
GUU88_RS10965 2250516..2250821 + 306 WP_001326990.1 hypothetical protein -
GUU88_RS10970 2251024..2251356 + 333 WP_001301033.1 protein FlxA -
GUU88_RS10975 2251793..2253106 - 1314 WP_000589005.1 ISNCY family transposase -
GUU88_RS22820 2254189..2254380 - 192 Protein_2144 hypothetical protein -
GUU88_RS10990 2254364..2254594 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
GUU88_RS10995 2254678..2255085 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
GUU88_RS11000 2255252..2255407 + 156 WP_000379575.1 DUF1391 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2235900..2267399 31499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T146827 WP_000323025.1 NZ_CP047594:c2250252-2249965 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T146827 NZ_CP062804:270503-270919 [Cupriavidus basilensis]
ATGTATTTGATTGACACCAATGTCATCAGTGAGATGAGGAAGCGCGAGCGTGCCGACAAGGGTGTTCGAGCATTCTTTCG
CCAAGCGGCAAAGCAGGAGAGTGAGCTGTACTTGTCGGTCGTCACTGTCGGCGAACTTCGGCGTGGCGTCGAGCTGATCC
AGCATCGGGGAGATCATGCGCAAGGCGCGCTTCTTGCCACGTGGCTCGACACGGTGCTGCAAGAGTTCGGGGCACATATC
CTCGCGGTAGATGCGGAAATCGGTCAGCTATGGGGGCGCCTTCGTGTCCCCCACGCGGAGCATGCCTTGGACAAACTGAT
CGCGGCGACGGCGCTGATTCACGACCTCACCGTAGTGACGCGCAACGTTAGTGATTTTGCTGGTACCGGGGCGCGTGTTC
TGAACCCCTTTGAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT146827 WP_000534858.1 NZ_CP047594:c2250491-2250252 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT146827 NZ_CP062804:270280-270516 [Cupriavidus basilensis]
ATGGCAAATCTGCTGGTTCGAGGGATTGATGAAGCGCTAGTACAGAGGCTGCGTGAGCAGGCTGCTGCACACGGTCGTAG
CGCTGAGGCCGAGCACCGTGAAATTCTTGCGCGGGCGTTGCACACGACCAGGCGCAAGAGCTTTGCCGAGGTGTTGGCAA
GCATGCCAGATGTCGGCGAGGACAGCGATTTCGAGCGCGTCGATCAGCCGGGCGGGGCCGCGCATGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References