216371

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1645343..1645869 Replicon chromosome
Accession NZ_CP083410
Organism Escherichia coli strain RP437

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LAJ62_RS08100 Protein ID WP_000323025.1
Coordinates 1645343..1645630 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag LAJ62_RS08105 Protein ID WP_000534858.1
Coordinates 1645630..1645869 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ62_RS08050 (1640367) 1640367..1640582 - 216 WP_000839590.1 phage lysis protein EssD -
LAJ62_RS08055 (1640802) 1640802..1640972 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
LAJ62_RS08060 (1641336) 1641336..1641551 - 216 WP_000066484.1 cold shock-like protein CspB -
LAJ62_RS08065 (1641852) 1641852..1642064 + 213 WP_000087756.1 cold shock-like protein CspF -
LAJ62_RS08070 (1642119) 1642119..1642208 + 90 WP_120795389.1 hypothetical protein -
LAJ62_RS08075 (1642486) 1642486..1643238 - 753 WP_001047135.1 antitermination protein -
LAJ62_RS08080 (1643252) 1643252..1644301 - 1050 WP_001265198.1 DUF968 domain-containing protein -
LAJ62_RS08085 (1644303) 1644303..1644581 - 279 WP_012304870.1 hypothetical protein -
LAJ62_RS08090 (1644648) 1644648..1644899 - 252 WP_000980994.1 protein Rem -
LAJ62_RS08095 (1645116) 1645116..1645271 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
LAJ62_RS08100 (1645343) 1645343..1645630 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LAJ62_RS08105 (1645630) 1645630..1645869 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LAJ62_RS08110 (1645894) 1645894..1646199 + 306 WP_001326990.1 protein YdfV -
LAJ62_RS08115 (1646402) 1646402..1646734 + 333 WP_001301033.1 FlxA-like family protein -
LAJ62_RS08120 (1647171) 1647171..1647320 - 150 WP_011443592.1 protein YdfW -
LAJ62_RS08125 (1647355) 1647355..1647633 - 279 Protein_1590 hypothetical protein -
LAJ62_RS08130 (1647617) 1647617..1647847 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
LAJ62_RS08135 (1647931) 1647931..1648338 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
LAJ62_RS08140 (1648505) 1648505..1648660 + 156 WP_000379575.1 DUF1391 family protein -
LAJ62_RS22530 (1648662) 1648662..1648790 + 129 WP_000344964.1 protein YdfB -
LAJ62_RS08145 (1648820) 1648820..1649038 + 219 WP_001171942.1 protein YdfC -
LAJ62_RS08150 (1649606) 1649606..1649794 + 189 WP_000854559.1 cell division inhibition protein DicB -
LAJ62_RS08155 (1649791) 1649791..1649982 + 192 WP_001083297.1 lysis protein YdfD -
LAJ62_RS08160 (1650075) 1650075..1650842 + 768 Protein_1598 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1630999..1664460 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T216371 WP_000323025.1 NZ_CP083410:c1645630-1645343 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T216371 NZ_CP113029:1403086-1403238 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT216371 WP_000534858.1 NZ_CP083410:c1645869-1645630 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT216371 NZ_CP113029:1402462-1403061 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References