208757

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1564159..1564685 Replicon chromosome
Accession NZ_CP077969
Organism Escherichia coli strain JM83

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KTJ86_RS07655 Protein ID WP_000323025.1
Coordinates 1564159..1564446 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KTJ86_RS07660 Protein ID WP_000534858.1
Coordinates 1564446..1564685 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ86_RS07605 (1559183) 1559183..1559398 - 216 WP_000839590.1 phage lysis protein EssD -
KTJ86_RS07610 (1559618) 1559618..1559788 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
KTJ86_RS07615 (1560152) 1560152..1560367 - 216 WP_000066484.1 cold shock-like protein CspB -
KTJ86_RS07620 (1560668) 1560668..1560880 + 213 WP_000087756.1 cold shock-like protein CspF -
KTJ86_RS07625 (1560935) 1560935..1561024 + 90 WP_120795389.1 hypothetical protein -
KTJ86_RS07630 (1561302) 1561302..1562054 - 753 WP_001047135.1 antitermination protein -
KTJ86_RS07635 (1562068) 1562068..1563117 - 1050 WP_001265198.1 DUF968 domain-containing protein -
KTJ86_RS07640 (1563119) 1563119..1563397 - 279 WP_012304870.1 hypothetical protein -
KTJ86_RS07645 (1563464) 1563464..1563715 - 252 WP_000980994.1 protein Rem -
KTJ86_RS07650 (1563932) 1563932..1564087 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KTJ86_RS07655 (1564159) 1564159..1564446 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KTJ86_RS07660 (1564446) 1564446..1564685 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KTJ86_RS07665 (1564710) 1564710..1565015 + 306 WP_001326990.1 protein YdfV -
KTJ86_RS07670 (1565218) 1565218..1565550 + 333 WP_001301033.1 FlxA-like family protein -
KTJ86_RS07675 (1565987) 1565987..1566136 - 150 WP_011443592.1 protein YdfW -
KTJ86_RS07680 (1566171) 1566171..1566449 - 279 Protein_1503 hypothetical protein -
KTJ86_RS07685 (1566433) 1566433..1566663 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
KTJ86_RS07690 (1566747) 1566747..1567154 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
KTJ86_RS07695 (1567321) 1567321..1567476 + 156 WP_000379575.1 DUF1391 family protein -
KTJ86_RS22030 (1567478) 1567478..1567606 + 129 WP_000344964.1 protein YdfB -
KTJ86_RS07700 (1567636) 1567636..1567854 + 219 WP_001171942.1 protein YdfC -
KTJ86_RS07705 (1568422) 1568422..1568610 + 189 WP_000854559.1 cell division inhibition protein DicB -
KTJ86_RS07710 (1568607) 1568607..1568798 + 192 WP_001083297.1 lysis protein YdfD -
KTJ86_RS07715 (1568891) 1568891..1569658 + 768 Protein_1511 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1549815..1583276 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T208757 WP_000323025.1 NZ_CP077969:c1564446-1564159 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T208757 NZ_CP103722:36833-37147 [Enterobacter hormaechei]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT208757 WP_000534858.1 NZ_CP077969:c1564685-1564446 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT208757 NZ_CP103722:37147-37563 [Enterobacter hormaechei]
ATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGAGAA
AGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGTCCTTTGCTGGATATTGTGTGCG
CCAGAATTAGCCATTACGAAGCTAATGGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGAATT
GCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGATGGT
TTCACGGGTTCTGAATGGTCAGAGACAGCTTACCCTGAACCATATTAAAAAGCTGGCGGCCAGATTTGGGGTATCACCTG
CGTTATTTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References