70553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2240948..2241474 Replicon chromosome
Accession NZ_CP018801
Organism Escherichia coli strain tolC-

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag BTD92_RS11810 Protein ID WP_000323025.1
Coordinates 2241187..2241474 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag BTD92_RS11805 Protein ID WP_000534858.1
Coordinates 2240948..2241187 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTD92_RS11735 2235975..2236742 - 768 Protein_2105 exonuclease -
BTD92_RS11740 2236835..2237026 - 192 WP_001083297.1 lysis protein YdfD -
BTD92_RS11745 2237023..2237211 - 189 WP_000854559.1 cell division inhibition protein DicB -
BTD92_RS11755 2237779..2237997 - 219 WP_001171942.1 hypothetical protein -
BTD92_RS11765 2238157..2238312 - 156 WP_000379575.1 DUF1391 family protein -
BTD92_RS11770 2238479..2238886 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
BTD92_RS11775 2238970..2239200 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
BTD92_RS11780 2239184..2239462 + 279 Protein_2112 hypothetical protein -
BTD92_RS11785 2239497..2239646 + 150 WP_011443592.1 hypothetical protein -
BTD92_RS11790 2240083..2240415 - 333 WP_001301033.1 protein FlxA -
BTD92_RS11800 2240618..2240923 - 306 WP_001326990.1 hypothetical protein -
BTD92_RS11805 2240948..2241187 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
BTD92_RS11810 2241187..2241474 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
BTD92_RS11815 2241546..2241701 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BTD92_RS11820 2241918..2242169 + 252 WP_000980994.1 hypothetical protein -
BTD92_RS11825 2242236..2242514 + 279 WP_012304870.1 hypothetical protein -
BTD92_RS11830 2242516..2243565 + 1050 WP_001265198.1 DUF968 domain-containing protein -
BTD92_RS11835 2243579..2244331 + 753 WP_001047135.1 antitermination protein -
BTD92_RS26185 2244609..2244698 - 90 WP_120795389.1 hypothetical protein -
BTD92_RS11840 2244753..2244965 - 213 WP_000087756.1 cold shock-like protein CspF -
BTD92_RS11845 2245266..2245481 + 216 WP_000066484.1 cold shock-like protein CspB -
BTD92_RS26740 2245845..2246015 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
BTD92_RS11850 2246235..2246450 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2221021..2255818 34797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T70553 WP_000323025.1 NZ_CP018801:2241187-2241474 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T70553 NZ_CP018801:2241187-2241474 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT70553 WP_000534858.1 NZ_CP018801:2240948-2241187 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT70553 NZ_CP018801:2240948-2241187 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References