Detailed information of TA system TA021458

Bioinformatically predicted

Overview

TA module

• Type: V
• Classification (family/domain): ghoTS/ghoT-GhoS
• Location: 4357262..4357759
• Replicon: chromosome
• Accession: NC_007779
• Organism: Escherichia coli str. K-12 substr. W3110

Toxin (Protein)

• Gene name: ghoT
• Uniprot ID: L4JJG6
• Locus tag: Y75_RS21550
• Protein ID: WP_001173343.1
• Coordinates: 4357586..4357759 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: ghoS
• Uniprot ID: L4JK92
• Locus tag: Y75_RS21545
• Protein ID: WP_000398619.1
• Coordinates: 4357262..4357558 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Y75_RS21525 (Y75_p4011)	4353993..4354712	-	720	WP_000611288.1	two-component system response regulator DcuR	-
Y75_RS21530 (Y75_p4012)	4354709..4356340	-	1632	WP_001216477.1	sensor histidine kinase	-
Y75_RS21535 (Y75_p4013)	4356521..4356751	+	231	WP_000371704.1	(4Fe-4S)-binding protein	-
Y75_RS21540 (Y75_p4014)	4356763..4357035	+	273	WP_000405651.1	N-acetyltransferase	-
Y75_RS21545 (Y75_p4015)	4357262..4357558	+	297	WP_000398619.1	type V toxin-antitoxin system endoribonuclease antitoxin GhoS	Antitoxin
Y75_RS21550 (Y75_p4016)	4357586..4357759	+	174	WP_001173343.1	type V toxin-antitoxin system toxin GhoT	Toxin
Y75_RS21555 (Y75_p4017)	4357878..4359395	-	1518	WP_001295074.1	lysine--tRNA ligase	-
Y75_RS21560 (Y75_p4018)	4359632..4361089	-	1458	WP_000856829.1	dipeptide/tripeptide permease DtpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View HG738867 Escherichia coli str. K-12 substr. MC4100 Genomic island TA020087 4238430..4247780 0 View NC_012759 Escherichia coli BW2952 Genomic island TA023874 4289342..4298692 0 View HG738867 Escherichia coli str. K-12 substr. MC4100 Genomic island TA020087 4238430..4247780 0 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Genomic island TA068443 4248154..4261393 0.009 View NZ_HG738867 Escherichia coli str. K-12 substr. MC4100 strain K-12 Genomic island TA285032 4238430..4247780 0 View NC_011415 Escherichia coli SE11 Genomic island TA023222 4623362..4632712 0.006 View NC_011741 Escherichia coli IAI1 Genomic island TA023346 4435948..4445299 0.007 View NC_013008 Escherichia coli O157:H7 str. TW14359 Genomic island TA024210 5238295..5247646 0.006 View NC_013941 Escherichia coli O55:H7 str. CB9615 Genomic island TA024626 5055800..5065151 0.006 View NC_017656 Escherichia coli O55:H7 str. RM12579 Genomic island TA027592 4964139..4973490 0.006 View NC_022364 Escherichia coli LY180 Genomic island TA030108 4543610..4552960 0 View NZ_AP019675 Escherichia coli strain GSH8M-2 Genomic island TA032880 4219046..4228397 0.004 View NZ_AP019856 Escherichia coli O8:H8 strain 16F5M1D1 Genomic island TA033207 4465602..4474953 0.007 View NZ_AP021890 Escherichia coli strain 2017.15.01CC Genomic island TA033519 277449..286800 0.007 View NZ_AP021891 Escherichia coli strain 2017.01.04CC Genomic island TA033567 4136377..4145728 0.003 View NZ_AP021894 Escherichia coli strain 2018-10-1CC Genomic island TA033632 4211462..4220818 0.005 View NZ_AP021895 Escherichia coli strain 2018-11-3CC Genomic island TA033651 4096676..4106027 0.003 View NZ_AP022177 Escherichia coli strain WP7-S17-ESBL-04 Genomic island TA034879 4257307..4266099 0.001 View NZ_AP022215 Escherichia coli strain WP8-S17-ESBL-05 Genomic island TA034975 4321709..4331060 0.007 View NZ_AP022245 Escherichia coli strain WP8-S18-CRE-02 Genomic island TA035084 4219046..4228397 0.004 View NZ_AP025205 Escherichia coli strain 2017.04.03CC Genomic island TA040088 4090753..4100104 0.003 View NZ_AP025209 Escherichia coli strain 2017.06.04CC Genomic island TA040113 4120509..4129865 0.005 View NZ_AP025546 Escherichia coli strain LR-06 Genomic island TA040393 4172758..4183154 0.006 View NZ_AP026087 Escherichia coli strain 8_140198 Genomic island TA041941 5187435..5196786 0.006 View NZ_AP026108 Escherichia coli strain CEC13091 Genomic island TA042266 5240556..5249907 0.007 View NZ_AP026110 Escherichia coli strain CEC08123 Genomic island TA042303 5104327..5113678 0.007 View NZ_AP026112 Escherichia coli strain CEC03102 Genomic island TA042342 5190209..5199560 0.007 View NZ_AP026961 Escherichia coli strain EC20-72C-1 Genomic island TA042942 4125545..4134896 0.003 View NZ_AP027424 Escherichia coli strain B27 isolate B27 Genomic island TA043993 4226222..4235573 0.004 View NZ_AP027445 Escherichia coli strain EC291 isolate EC291 Genomic island TA044128 4111547..4120903 0.005 View NZ_CP008801 Escherichia coli KLY Genomic island TA047529 4429443..4438793 0 View NZ_CP010145 Escherichia coli strain D5 Genomic island TA050785 3760034..3769385 0.006 View NZ_CP010160 Escherichia coli strain H1 Genomic island TA050962 2835048..2844399 0.004 View NZ_CP010200 Escherichia coli strain M10 Genomic island TA051340 2945715..2955065 0.007 View NZ_CP010230 Escherichia coli strain S21 Genomic island TA051576 3842987..3852338 0.007 View NZ_CP010238 Escherichia coli strain S50 Genomic island TA051691 2418704..2428055 0.007 View NZ_CP010442 Escherichia coli K-12 strain K-12 MG1655 Genomic island TA052568 468745..478095 0 View NZ_CP010445 Escherichia coli K-12 strain K-12 MG1655 Genomic island TA052692 468745..478095 0 View NZ_CP013483 Escherichia coli strain Y5 Genomic island TA058836 4735768..4743900 0.008 View NZ_CP013952 Escherichia coli strain HST04 Genomic island TA059653 1527513..1536380 0.001 View NZ_CP014270 Escherichia coli K-12 strain K-12 DHB4 Genomic island TA060547 4257785..4267135 0 View NZ_CP015912 Escherichia coli strain 210205630 Genomic island TA063914 3314959..3324310 0.007 View NZ_CP018109 Escherichia coli strain MRSN346595 Genomic island TA068748 4531147..4540497 0 View NZ_CP018239 Escherichia coli strain 272 Genomic island TA069044 5182877..5192228 0.007 View NZ_CP018840 Escherichia coli strain KSC64 Genomic island TA070670 2113810..2123159 0.006 View NZ_CP019051 Escherichia coli strain CRE1540 Genomic island TA071615 895414..904764 0.006 View NZ_CP019256 Escherichia coli strain 13TMH22 Genomic island TA072010 1181049..1190400 0.007 View NZ_CP019259 Escherichia coli strain 13C1065T Genomic island TA072049 4600945..4611123 0.006 View NZ_CP019361 Escherichia coli strain XH993 Genomic island TA072351 4263122..4272473 0.004 View NZ_CP020368 Escherichia coli strain BLR(DE3) Genomic island TA074436 4251527..4260878 0.004 View NZ_CP021202 Escherichia coli strain Z1002 Genomic island TA076226 1015543..1024893 0.009 View NZ_CP023377 Escherichia coli strain 127 Genomic island TA081051 4272358..4281644 0.009 View NZ_CP023541 Escherichia coli O104:H21 str. CFSAN002236 strain ATCC BAA-178 Genomic island TA081582 483462..492812 0.007 View NZ_CP024127 Escherichia coli strain 14EC001 Genomic island TA086802 4596460..4605811 0.003 View NZ_CP024479 Escherichia coli strain 2011C-4315 Genomic island TA087771 2742724..2752075 0.007 View NZ_CP024978 Escherichia coli strain CV839-15 Genomic island TA089397 1840239..1849590 0.007 View NZ_CP025847 Escherichia coli strain 602354 Genomic island TA092060 2278634..2287985 0.007 View NZ_CP027219 Escherichia coli strain 2015C-3163 Genomic island TA097667 4708497..4717848 0.007 View NZ_CP027362 Escherichia coli strain 95-3192 Genomic island TA098334 3511953..3521304 0.006 View NZ_CP028746 Escherichia coli strain A29 Genomic island TA103460 4223687..4232555 0.007 View NZ_CP028756 Escherichia coli strain A19 Genomic island TA103705 4566677..4577345 0.01 View NZ_CP029242 Escherichia coli strain ECCRA-119 Genomic island TA105335 4393399..4402749 0.006 View NZ_CP030331 Escherichia coli strain AR_452 Genomic island TA107740 4318664..4328014 0.006 View NZ_CP031345 Escherichia coli O145 strain RM12367-C1 Genomic island TA109018 5105938..5115289 0.006 View NZ_CP031349 Escherichia coli O145 strain RM9467-C1 Genomic island TA109076 5019432..5028783 0.006 View NZ_CP031908 Escherichia coli O103:H2 strain FWSEC0007 Genomic island TA110631 4903935..4913286 0.007 View NZ_CP032073 Escherichia coli strain CT29 Genomic island TA111010 4118414..4127054 0.005 View NZ_CP032237 Escherichia coli strain ECCWS199 Genomic island TA111446 4257703..4267058 0.002 View NZ_CP032892 Escherichia coli strain SCEC020022 Genomic island TA112789 4394104..4403454 0.006 View NZ_CP034794 Escherichia coli strain 06-3462 Genomic island TA116632 4962650..4972001 0.006 View NZ_CP034797 Escherichia coli strain 08-3918 Genomic island TA116665 3433148..3442499 0.007 View NZ_CP035312 Escherichia coli strain D72 Genomic island TA117599 4091198..4100549 0.003 View NZ_CP035817 Escherichia coli strain E7476 Genomic island TA118593 4760675..4770026 0.006 View NZ_CP038376 Escherichia coli O157:H7 strain F1273 Genomic island TA122146 459774..469125 0.006 View NZ_CP038428 Escherichia coli O157:H7 strain 611 Genomic island TA122780 4882418..4891769 0.006 View NZ_CP039298 Escherichia coli strain PigCaeca_1 Genomic island TA123792 2470510..2480906 0.006 View NZ_CP040307 Escherichia coli strain F1 E4 Genomic island TA125319 460071..469422 0.006 View NZ_CP040397 Escherichia coli strain BA22372 Genomic island TA125729 1139675..1149026 0.006 View NZ_CP041110 Escherichia coli strain ECCTRSRTH03 Genomic island TA127619 4174029..4183380 0.004 View NZ_CP042844 Escherichia coli strain JME66 Genomic island TA136111 416658..426008 0 View NZ_CP043185 Escherichia coli O16:H48 strain PG20180171 Genomic island TA137446 3083131..3092481 0 View NZ_CP043486 Escherichia coli strain SL112 Genomic island TA138855 4498171..4507521 0 View NZ_CP044145 Escherichia coli O157 strain AR-0428 Genomic island TA140266 4975035..4984384 0.007 View NZ_CP044293 Escherichia coli strain P276M Genomic island TA140536 2725863..2735218 0.002 View NZ_CP044314 Escherichia coli strain RM9245 Genomic island TA140641 2384455..2393805 0.007 View NZ_CP047576 Escherichia coli strain 94EC Genomic island TA146775 2333068..2342418 0.006 View NZ_CP047665 Escherichia coli strain LD26-1 Genomic island TA147154 3618656..3628007 0.006 View NZ_CP048025 Escherichia coli strain GZEC065 Genomic island TA148725 3548085..3557435 0.006 View NZ_CP049353 Escherichia coli strain T28R Genomic island TA151305 4138365..4147720 0.002 View NZ_CP050040 Escherichia coli strain 63-2 Genomic island TA152096 4037849..4047204 0.002 View NZ_CP050498 Escherichia coli strain RM13322 Genomic island TA152947 2971293..2980644 0.007 View NZ_CP051158 Escherichia coli strain 17MR471 Genomic island TA153593 1025880..1035231 0.003 View NZ_CP051222 Escherichia coli strain SCZE5 Genomic island TA153903 4337504..4346855 0.004 View NZ_CP053234 Escherichia coli strain SCU-106 Genomic island TA156337 2233750..2243100 0.006 View NZ_CP053604 Escherichia coli strain NEB10-beta Genomic island TA157120 4432596..4441946 0 View NZ_CP053731 Escherichia coli strain CP55_Sichuan Genomic island TA157632 2409745..2419096 0.006 View NZ_CP053787 Escherichia coli isolate J31 Genomic island TA157820 273190..282541 0.003 View NZ_CP054665 Escherichia coli strain IGC_EcoliInv_1.1 Genomic island TA160066 4404375..4413725 0 View NZ_CP058725 Escherichia coli strain S171-1 Genomic island TA167285 2645759..2655110 0.003 View NZ_CP059283 Escherichia coli strain SY3626_hybrid Genomic island TA168513 4150712..4160063 0.003 View NZ_CP060974 Escherichia coli strain EC4 Genomic island TA171840 4371811..4382938 0.008 View NZ_CP062240 Escherichia coli strain AML001_ev02 Genomic island TA173709 4343600..4352950 0 View NZ_CP063332 Escherichia coli strain BS74R-D Genomic island TA177917 3418575..3427925 0 View NZ_CP065607 Escherichia coli strain FDAARGOS_946 Genomic island TA182963 2738005..2747356 0.006 View NZ_CP067265 Escherichia coli strain ABW_S38 Genomic island TA185991 2462944..2472295 0.004 View NZ_CP067311 Escherichia coli strain 027_SK3 Genomic island TA186113 2462846..2472197 0.004 View NZ_CP067426 Escherichia coli O22:H8 strain 154 Genomic island TA186354 5082990..5092341 0.007 View NZ_CP068283 Escherichia coli strain CY598 Genomic island TA187116 4400356..4409706 0 View NZ_CP068680 Escherichia coli strain NCCP12480 Genomic island TA187492 602842..612193 0.004 View NZ_CP069712 Escherichia coli strain EA13 Genomic island TA191766 4238007..4247363 0.005 View NZ_CP070902 Escherichia coli strain 99COLEC Genomic island TA194614 4258205..4267561 0.005 View NZ_CP070906 Escherichia coli strain 88COLEC Genomic island TA194636 4386809..4396160 0.006 View NZ_CP071711 Escherichia coli strain EC20017429 Genomic island TA196763 2368238..2377589 0.007 View NZ_CP072054 Escherichia coli strain K1508 Genomic island TA197279 4237929..4247279 0 View NZ_CP073924 Escherichia coli strain MB165 Genomic island TA200562 4328258..4337608 0.006 View NZ_CP073996 Escherichia coli strain PM7 Genomic island TA201001 3392987..3402337 0 View NZ_CP074019 Escherichia coli strain PM22 Genomic island TA201101 278641..287992 0.008 View NZ_CP074024 Escherichia coli strain PK5 Genomic island TA201158 4189063..4198418 0.002 View NZ_CP075627 Escherichia coli strain P15-385 Genomic island TA203982 276342..285692 0.007 View NZ_CP075716 Escherichia coli strain CPww7 Genomic island TA204289 2593243..2602594 0.007 View NZ_CP076262 Escherichia coli strain 0-4 Genomic island TA205079 4716979..4726330 0.007 View NZ_CP076272 Escherichia coli strain E21845/O/A Genomic island TA205211 4677762..4687113 0.007 View NZ_CP079767 Escherichia coli strain SF10 Genomic island TA209982 2994163..3003513 0 View NZ_CP079770 Escherichia coli strain HL15 Genomic island TA210007 2999352..3008702 0 View NZ_CP079992 Escherichia coli strain KMS2001 Genomic island TA210482 602945..612295 0 View NZ_CP080121 Escherichia coli strain PK8217 Genomic island TA210947 3984741..3994096 0.002 View NZ_CP080133 Escherichia coli strain PK8277 Genomic island TA211008 4126167..4135522 0.002 View NZ_CP080172 Escherichia coli strain PK8566 Genomic island TA211178 290924..300275 0.006 View NZ_CP083492 Escherichia coli strain elppa8 Genomic island TA216577 3075013..3083145 0.009 View NZ_CP083869 Escherichia coli strain NDM6 Genomic island TA217626 4244896..4253683 0.002 View NZ_CP090305 Escherichia coli strain Z503 Genomic island TA230397 520938..530289 0.004 View NZ_CP091756 Escherichia coli strain LC-1302-2020 Genomic island TA234720 4530190..4544448 0.01 View NZ_CP091839 Escherichia coli strain SWYHX138.261ft Genomic island TA234871 3454048..3463399 0.007 View NZ_CP095088 Escherichia coli isolate w264 Genomic island TA241296 4227149..4236435 0.009 View NZ_CP101513 Escherichia coli strain HH194M Genomic island TA252178 4195335..4205741 0.007 View NZ_CP101915 Escherichia coli strain Evo1 Genomic island TA252922 4194904..4204381 0.003 View NZ_CP102379 Escherichia coli strain BM28 lysU Genomic island TA253555 4228837..4237719 0.007 View NZ_CP102380 Escherichia coli strain BM28 Genomic island TA253589 4229976..4239326 0 View NZ_CP103694 Escherichia coli strain ST12468 Genomic island TA256211 4173774..4183125 0.004 View NZ_CP104114 Escherichia coli strain USDA-ARS-USMARC-51408 Genomic island TA257217 445660..455010 0 View NZ_CP104536 Escherichia coli strain E3 Genomic island TA258363 4179423..4188774 0.006 View NZ_CP104629 Escherichia coli strain AHM21C2872I Genomic island TA258685 4357699..4367050 0.006 View NZ_CP116046 Escherichia coli strain EC812A1 Genomic island TA267738 3411948..3424329 0.008 View NZ_CP116106 Escherichia coli strain DETEC-P829 Genomic island TA268000 4360525..4369876 0.007 View NZ_CP116923 Escherichia coli strain MLI104K1 Genomic island TA269447 4209783..4218146 0.003 View NZ_CP122634 Escherichia coli strain ETEC4085 Genomic island TA277459 4725665..4735021 0.005 View NZ_CP123951 Escherichia coli strain TL012 Genomic island TA279230 812194..821549 0.002 View NZ_CP123963 Escherichia coli strain L6-21 Genomic island TA279288 4161258..4170609 0.004 View NZ_CP126343 Escherichia coli strain DAX4 Genomic island TA282864 4240537..4249893 0.005 View NZ_LM993812 Escherichia coli strain K-12 substr. HMS174 Genomic island TA285413 4295792..4305142 0 View NZ_LR025096 Escherichia coli isolate EC-7215 Genomic island TA285849 489923..499273 0.006 View NZ_LR134075 Escherichia coli strain NCTC9084 Genomic island TA286623 4124916..4133708 0.001 View NZ_LR134079 Escherichia coli strain NCTC9112 Genomic island TA286646 4965027..4974375 0.008 View NZ_LR134228 Escherichia coli strain NCTC9699 Genomic island TA287207 4459534..4468885 0.005 View NZ_LR134248 Escherichia coli strain NCTC10537 Genomic island TA287393 4108046..4116839 0.005 View NZ_LR882057 Escherichia coli isolate 2014-01-7375 Genomic island TA289622 4505244..4514595 0.007 View NZ_LR882973 Escherichia coli isolate L2_E1649 Genomic island TA290011 4247266..4256497 0.008 View NZ_LT615378 Escherichia coli isolate 103 Genomic island TA293388 4349058..4358408 0 View NC_012759 Escherichia coli BW2952 Genomic island TA023874 4289342..4298692 0 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Genomic island TA068443 4248154..4261393 0.009 View NZ_HG738867 Escherichia coli str. K-12 substr. MC4100 strain K-12 Genomic island TA285032 4238430..4247780 0	inside	Genomic island	-	-	4357262..4366612	9350

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6555.06 Da
• Isoelectric Point: 10.2288

>T21458 WP_001173343.1 NC_007779:4357586-4357759 [Escherichia coli str. K-12 substr. W3110]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Nucleotide

• Length: 174 bp

>T21458 NC_007779:4357586-4357759 [Escherichia coli str. K-12 substr. W3110]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11467.97 Da
• Isoelectric Point: 4.1705

>AT21458 WP_000398619.1 NC_007779:4357262-4357558 [Escherichia coli str. K-12 substr. W3110]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Nucleotide

• Length: 297 bp

>AT21458 NC_007779:4357262-4357558 [Escherichia coli str. K-12 substr. W3110]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A7U9QI41

Antitoxin

• PDB: 2LLZ
• AlphaFold DB: A0A7U9QBH6