269447

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4217649..4218146 Replicon chromosome
Accession NZ_CP116923
Organism Escherichia coli strain MLI104K1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NL419_RS21440 Protein ID WP_001173343.1
Coordinates 4217649..4217822 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag NL419_RS21445 Protein ID WP_255055505.1
Coordinates 4217850..4218146 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL419_RS21430 (4214319) 4214319..4215776 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NL419_RS21435 (4216013) 4216013..4217530 + 1518 WP_072667412.1 lysine--tRNA ligase -
NL419_RS21440 (4217649) 4217649..4217822 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NL419_RS21445 (4217850) 4217850..4218146 - 297 WP_255055505.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NL419_RS21450 (4218373) 4218373..4218645 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
NL419_RS21455 (4218657) 4218657..4218887 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
NL419_RS21460 (4219068) 4219068..4220699 + 1632 WP_001216477.1 sensor histidine kinase -
NL419_RS21465 (4220696) 4220696..4221415 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4209783..4218146 8363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269447 WP_001173343.1 NZ_CP116923:c4217822-4217649 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11453.95 Da        Isoelectric Point: 4.1705

>AT269447 WP_255055505.1 NZ_CP116923:c4218146-4217850 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLVRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References