290011

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4256000..4256497 Replicon chromosome
Accession NZ_LR882973
Organism Escherichia coli isolate L2_E1649

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag JLZ81_RS20815 Protein ID WP_001173343.1
Coordinates 4256000..4256173 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A2U9LI53
Locus tag JLZ81_RS20820 Protein ID WP_071597404.1
Coordinates 4256201..4256497 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ81_RS20805 4252665..4254122 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
JLZ81_RS20810 4254359..4255876 + 1518 WP_001295074.1 lysine--tRNA ligase -
JLZ81_RS20815 4256000..4256173 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
JLZ81_RS20820 4256201..4256497 - 297 WP_071597404.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
JLZ81_RS20825 4256724..4256996 - 273 WP_000405647.1 N-acetyltransferase -
JLZ81_RS20830 4257008..4257238 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
JLZ81_RS20835 4257419..4259050 + 1632 WP_001216490.1 sensor histidine kinase -
JLZ81_RS20840 4259047..4259766 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4247266..4256497 9231


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(6-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T290011 WP_001173343.1 NZ_LR882973:c4256173-4256000 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11495.99 Da        Isoelectric Point: 4.1705

>AT290011 WP_071597404.1 NZ_LR882973:c4256497-4256201 [Escherichia coli]
MEGKNRFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9LI53

References