252922

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4203884..4204381 Replicon chromosome
Accession NZ_CP101915
Organism Escherichia coli strain Evo1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NP443_RS20480 Protein ID WP_001173343.1
Coordinates 4203884..4204057 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NP443_RS20485 Protein ID WP_000398619.1
Coordinates 4204085..4204381 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP443_RS20470 (4200554) 4200554..4202011 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NP443_RS20475 (4202248) 4202248..4203765 + 1518 WP_001295074.1 lysine--tRNA ligase -
NP443_RS20480 (4203884) 4203884..4204057 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NP443_RS20485 (4204085) 4204085..4204381 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NP443_RS20490 (4204608) 4204608..4204880 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
NP443_RS20495 (4204892) 4204892..4205122 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
NP443_RS20500 (4205303) 4205303..4206934 + 1632 WP_001216477.1 sensor histidine kinase -
NP443_RS20505 (4206931) 4206931..4207650 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4194904..4204381 9477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T252922 WP_001173343.1 NZ_CP101915:c4204057-4203884 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT252922 WP_000398619.1 NZ_CP101915:c4204381-4204085 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References