Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4514098..4514595 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name ghoT Uniprot ID -
Locus tag IHP09_RS21840 Protein ID WP_121865734.1
Coordinates 4514098..4514271 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag IHP09_RS21845 Protein ID WP_000398619.1
Coordinates 4514299..4514595 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS21830 4510768..4512225 + 1458 WP_000856832.1 dipeptide/tripeptide permease DtpC -
IHP09_RS21835 4512462..4513979 + 1518 WP_001295087.1 lysine--tRNA ligase -
IHP09_RS21840 4514098..4514271 - 174 WP_121865734.1 type V toxin-antitoxin system toxin GhoT Toxin
IHP09_RS21845 4514299..4514595 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
IHP09_RS21850 4514822..4515094 - 273 WP_000405647.1 N-acetyltransferase -
IHP09_RS21855 4515106..4515336 - 231 WP_000371698.1 (4Fe-4S)-binding protein -
IHP09_RS21860 4515517..4517148 + 1632 WP_001216487.1 sensor histidine kinase -
IHP09_RS21865 4517145..4517864 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4505244..4514595 9351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(6-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6521.04 Da        Isoelectric Point: 10.2288

>T289622 WP_121865734.1 NZ_LR882057:c4514271-4514098 [Escherichia coli]
MALLSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT289622 WP_000398619.1 NZ_LR882057:c4514595-4514299 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References