24626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 5055800..5056297 Replicon chromosome
Accession NC_013941
Organism Escherichia coli O55:H7 str. CB9615

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag G2583_RS25515 Protein ID WP_001173343.1
Coordinates 5056124..5056297 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag G2583_RS25510 Protein ID WP_000398619.1
Coordinates 5055800..5056096 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G2583_RS25490 5052531..5053250 - 720 WP_000611288.1 two-component system response regulator DcuR -
G2583_RS25495 5053247..5054878 - 1632 WP_001216477.1 sensor histidine kinase -
G2583_RS25500 5055059..5055289 + 231 WP_000371704.1 (4Fe-4S)-binding protein -
G2583_RS25505 5055301..5055573 + 273 WP_000405642.1 N-acetyltransferase -
G2583_RS25510 5055800..5056096 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
G2583_RS25515 5056124..5056297 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
G2583_RS25520 5056416..5057933 - 1518 WP_001295074.1 lysine--tRNA ligase -
G2583_RS25525 5058170..5059627 - 1458 WP_000856824.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5055800..5065151 9351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T24626 WP_001173343.1 NC_013941:5056124-5056297 [Escherichia coli O55:H7 str. CB9615]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T24626 NC_013941:5056124-5056297 [Escherichia coli O55:H7 str. CB9615]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT24626 WP_000398619.1 NC_013941:5055800-5056096 [Escherichia coli O55:H7 str. CB9615]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT24626 NC_013941:5055800-5056096 [Escherichia coli O55:H7 str. CB9615]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References