210007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3008205..3008702 Replicon chromosome
Accession NZ_CP079770
Organism Escherichia coli strain HL15

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag KYX58_RS16415 Protein ID WP_001173343.1
Coordinates 3008205..3008378 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag KYX58_RS16420 Protein ID WP_000398619.1
Coordinates 3008406..3008702 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX58_RS16405 (3004875) 3004875..3006332 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
KYX58_RS16410 (3006569) 3006569..3008086 + 1518 WP_001295074.1 lysine--tRNA ligase -
KYX58_RS16415 (3008205) 3008205..3008378 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
KYX58_RS16420 (3008406) 3008406..3008702 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
KYX58_RS16425 (3008929) 3008929..3009201 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
KYX58_RS16430 (3009213) 3009213..3009443 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
KYX58_RS16435 (3009624) 3009624..3011255 + 1632 WP_001216477.1 sensor histidine kinase -
KYX58_RS16440 (3011252) 3011252..3011971 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2999352..3008702 9350


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T210007 WP_001173343.1 NZ_CP079770:c3008378-3008205 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T210007 NZ_CP104363:c56671-56366 [Salmonella enterica]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT210007 WP_000398619.1 NZ_CP079770:c3008702-3008406 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT210007 NZ_CP104363:c56891-56673 [Salmonella enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References