Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3454048..3454545 Replicon chromosome
Accession NZ_CP091839
Organism Escherichia coli strain SWYHX138.261ft

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag L7H22_RS16595 Protein ID WP_001173343.1
Coordinates 3454372..3454545 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag L7H22_RS16590 Protein ID WP_095716590.1
Coordinates 3454048..3454344 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H22_RS16570 (3450779) 3450779..3451498 - 720 WP_000611288.1 two-component system response regulator DcuR -
L7H22_RS16575 (3451495) 3451495..3453126 - 1632 WP_001216477.1 sensor histidine kinase -
L7H22_RS16580 (3453307) 3453307..3453537 + 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
L7H22_RS16585 (3453549) 3453549..3453821 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
L7H22_RS16590 (3454048) 3454048..3454344 + 297 WP_095716590.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
L7H22_RS16595 (3454372) 3454372..3454545 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
L7H22_RS16600 (3454664) 3454664..3456181 - 1518 WP_112911841.1 lysine--tRNA ligase -
L7H22_RS16605 (3456418) 3456418..3457875 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3454048..3463399 9351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T234871 WP_001173343.1 NZ_CP091839:3454372-3454545 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T234871 NZ_LR134093:c2242443-2242339 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11495.04 Da        Isoelectric Point: 4.2931

>AT234871 WP_095716590.1 NZ_CP091839:3454048-3454344 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMKVDDYFRQFYK

Download         Length: 297 bp

>AT234871 NZ_LR134093:2242246-2242284 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References