282864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4249396..4249893 Replicon chromosome
Accession NZ_CP126343
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QN220_RS20475 Protein ID WP_001173343.1
Coordinates 4249396..4249569 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QN220_RS20480 Protein ID WP_000398619.1
Coordinates 4249597..4249893 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS20465 (4246061) 4246061..4247518 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QN220_RS20470 (4247755) 4247755..4249272 + 1518 WP_284562122.1 lysine--tRNA ligase -
QN220_RS20475 (4249396) 4249396..4249569 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QN220_RS20480 (4249597) 4249597..4249893 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QN220_RS20485 (4250120) 4250120..4250392 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QN220_RS20490 (4250404) 4250404..4250634 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QN220_RS20495 (4250815) 4250815..4252446 + 1632 WP_153443403.1 sensor histidine kinase -
QN220_RS20500 (4252443) 4252443..4253162 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4240537..4249893 9356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T282864 WP_001173343.1 NZ_CP126343:c4249569-4249396 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT282864 WP_000398619.1 NZ_CP126343:c4249893-4249597 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References