286646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4973866..4974375 Replicon chromosome
Accession NZ_LR134079
Organism Escherichia coli strain NCTC9112

Toxin (Protein)


Gene name ghoT Uniprot ID -
Locus tag EL053_RS24880 Protein ID WP_089514152.1
Coordinates 4973866..4974051 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag EL053_RS24885 Protein ID WP_000398619.1
Coordinates 4974079..4974375 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL053_RS24870 4970550..4972007 + 1458 WP_000856824.1 dipeptide/tripeptide permease DtpC -
EL053_RS24875 4972244..4973760 + 1517 Protein_4766 lysine--tRNA ligase -
EL053_RS24880 4973866..4974051 - 186 WP_089514152.1 type V toxin-antitoxin system toxin GhoT Toxin
EL053_RS24885 4974079..4974375 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
EL053_RS24890 4974602..4974874 - 273 WP_000405653.1 N-acetyltransferase -
EL053_RS24895 4974886..4975116 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
EL053_RS24900 4975297..4976928 + 1632 WP_001216470.1 sensor histidine kinase -
EL053_RS24905 4976925..4977644 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4965027..4974375 9348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-54)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6988.54 Da        Isoelectric Point: 10.2380

>T286646 WP_089514152.1 NZ_LR134079:c4974051-4973866 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFLSFRSCS

Download         Length: 186 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT286646 WP_000398619.1 NZ_LR134079:c4974375-4974079 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References