252178

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4205244..4205741 Replicon chromosome
Accession NZ_CP101513
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag MOO21_RS20425 Protein ID WP_001173343.1
Coordinates 4205244..4205417 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag MOO21_RS20430 Protein ID WP_000398619.1
Coordinates 4205445..4205741 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS20415 (4201914) 4201914..4203371 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
MOO21_RS20420 (4203608) 4203608..4205125 + 1518 WP_001295074.1 lysine--tRNA ligase -
MOO21_RS20425 (4205244) 4205244..4205417 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
MOO21_RS20430 (4205445) 4205445..4205741 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
MOO21_RS20435 (4205968) 4205968..4206240 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
MOO21_RS20440 (4206252) 4206252..4206482 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
MOO21_RS20445 (4206663) 4206663..4208294 + 1632 WP_001565376.1 sensor histidine kinase -
MOO21_RS20450 (4208291) 4208291..4209010 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4195335..4205741 10406


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T252178 WP_001173343.1 NZ_CP101513:c4205417-4205244 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT252178 WP_000398619.1 NZ_CP101513:c4205741-4205445 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References