196763

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2377092..2377589 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag JQM62_RS11940 Protein ID WP_001173343.1
Coordinates 2377092..2377265 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag JQM62_RS11945 Protein ID WP_000398619.1
Coordinates 2377293..2377589 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS11930 (2373762) 2373762..2375219 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
JQM62_RS11935 (2375456) 2375456..2376973 + 1518 WP_001295074.1 lysine--tRNA ligase -
JQM62_RS11940 (2377092) 2377092..2377265 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
JQM62_RS11945 (2377293) 2377293..2377589 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
JQM62_RS11950 (2377816) 2377816..2378088 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
JQM62_RS11955 (2378100) 2378100..2378330 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
JQM62_RS11960 (2378511) 2378511..2380142 + 1632 WP_001216487.1 sensor histidine kinase -
JQM62_RS11965 (2380139) 2380139..2380858 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2368238..2377589 9351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T196763 WP_001173343.1 NZ_CP071711:c2377265-2377092 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T196763 NZ_CP095407:479178-479567 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTGTTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCACAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACTGTGGGGAAATTACTAAGATAATTGATTATCAGTTGTTTGTGGTTATTTATCTTGAAGAAACTCCTACGAATATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGATAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT196763 WP_000398619.1 NZ_CP071711:c2377589-2377293 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT196763 NZ_CP095407:478914-479171 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAATTATTATTTAAAAGCTGATCCGGCTGAAAAAGCATTATTTGCAGAGTTGGTTGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References