267738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3422073..3422905 Replicon chromosome
Accession NZ_CP116046
Organism Escherichia coli strain EC812A1

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag PIH14_RS16505 Protein ID WP_000854753.1
Coordinates 3422073..3422447 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag PIH14_RS16510 Protein ID WP_001278232.1
Coordinates 3422537..3422905 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIH14_RS16490 (3417737) 3417737..3419071 - 1335 WP_000092909.1 cadaverine/lysine antiporter -
PIH14_RS16495 (3419436) 3419436..3420974 - 1539 WP_001187173.1 lysine decarboxylation/transport transcriptional activator CadC -
PIH14_RS16500 (3421723) 3421723..3422076 - 354 WP_071685956.1 DUF5983 family protein -
PIH14_RS16505 (3422073) 3422073..3422447 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
PIH14_RS16510 (3422537) 3422537..3422905 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
PIH14_RS16515 (3423068) 3423068..3423289 - 222 WP_000692311.1 DUF987 domain-containing protein -
PIH14_RS16520 (3423352) 3423352..3423828 - 477 WP_001186770.1 RadC family protein -
PIH14_RS16525 (3423844) 3423844..3424329 - 486 WP_000849576.1 antirestriction protein -
PIH14_RS16530 (3424384) 3424384..3425202 - 819 WP_001234620.1 DUF932 domain-containing protein -
PIH14_RS16535 (3425302) 3425302..3425535 - 234 WP_001119729.1 DUF905 family protein -
PIH14_RS16540 (3425614) 3425614..3426069 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3411948..3424329 12381


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T267738 WP_000854753.1 NZ_CP116046:c3422447-3422073 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT267738 WP_001278232.1 NZ_CP116046:c3422905-3422537 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References