268000

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4369379..4369876 Replicon chromosome
Accession NZ_CP116106
Organism Escherichia coli strain DETEC-P829

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PIC05_RS21210 Protein ID WP_001173343.1
Coordinates 4369379..4369552 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PIC05_RS21215 Protein ID WP_000398619.1
Coordinates 4369580..4369876 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC05_RS21200 (4366049) 4366049..4367506 + 1458 WP_000856832.1 dipeptide/tripeptide permease DtpC -
PIC05_RS21205 (4367743) 4367743..4369260 + 1518 WP_001295087.1 lysine--tRNA ligase -
PIC05_RS21210 (4369379) 4369379..4369552 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PIC05_RS21215 (4369580) 4369580..4369876 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PIC05_RS21220 (4370103) 4370103..4370375 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PIC05_RS21225 (4370387) 4370387..4370617 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
PIC05_RS21230 (4370798) 4370798..4372429 + 1632 WP_001216487.1 sensor histidine kinase -
PIC05_RS21235 (4372426) 4372426..4373145 + 720 WP_271292831.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4360525..4369876 9351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T268000 WP_001173343.1 NZ_CP116106:c4369552-4369379 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT268000 WP_000398619.1 NZ_CP116106:c4369876-4369580 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References