Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4734524..4735021 Replicon chromosome
Accession NZ_CP122634
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW62_RS23730 Protein ID WP_001173343.1
Coordinates 4734524..4734697 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW62_RS23735 Protein ID WP_000398619.1
Coordinates 4734725..4735021 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS23720 (4731189) 4731189..4732646 + 1458 WP_032167241.1 dipeptide/tripeptide permease DtpC -
QDW62_RS23725 (4732883) 4732883..4734400 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDW62_RS23730 (4734524) 4734524..4734697 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW62_RS23735 (4734725) 4734725..4735021 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW62_RS23740 (4735248) 4735248..4735520 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDW62_RS23745 (4735532) 4735532..4735762 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDW62_RS23750 (4735943) 4735943..4737574 + 1632 WP_001216477.1 sensor histidine kinase -
QDW62_RS23755 (4737571) 4737571..4738290 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4725665..4735021 9356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277459 WP_001173343.1 NZ_CP122634:c4734697-4734524 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277459 WP_000398619.1 NZ_CP122634:c4735021-4734725 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References