Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 821052..821549 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QGM68_RS03995 Protein ID WP_001173343.1
Coordinates 821052..821225 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QGM68_RS04000 Protein ID WP_000398619.1
Coordinates 821253..821549 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS03985 (817717) 817717..819174 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QGM68_RS03990 (819411) 819411..820928 + 1518 WP_001295074.1 lysine--tRNA ligase -
QGM68_RS03995 (821052) 821052..821225 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QGM68_RS04000 (821253) 821253..821549 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QGM68_RS04005 (821776) 821776..822048 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QGM68_RS04010 (822060) 822060..822290 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QGM68_RS04015 (822471) 822471..824102 + 1632 WP_001216477.1 sensor histidine kinase -
QGM68_RS04020 (824099) 824099..824818 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 812194..821549 9355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T279230 WP_001173343.1 NZ_CP123951:c821225-821052 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT279230 WP_000398619.1 NZ_CP123951:c821549-821253 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References