Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type I Classification (family/domain) bsrG-as-bsrG/-
Location 2273594..2273884 Replicon chromosome
Accession NC_000964
Organism Bacillus subtilis subsp. subtilis str. 168
T1TAdb ID TA04735

Toxin (Protein)


Gene name bsrG Uniprot ID -
Locus tag BSU21546 Protein ID YP_009513970.1
Coordinates 2273594..2273710 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrG
Locus tag BSU_misc_RNA_77
Coordinates 2273705..2273884 (-)

Genomic Context

BSU_21520BSU_21546BSU_21480BSU_21490BSU_21500BSU_21510BSU_21530BSU_21540BSU_misc_RNA_77-BSU_21550BSU_21560BSU_21570BSU_21580BSU_21590
Location: 2272156..2272491 (336 bp)
Type: Others
Protein ID: NP_390035.1
Location: 2273594..2273710 (117 bp)
Type: Toxin
Protein ID: YP_009513970.1
Location: 2269521..2269691 (171 bp)
Type: Others
Protein ID: NP_390031.1
Location: 2269988..2270305 (318 bp)
Type: Others
Protein ID: NP_390032.1
Location: 2270407..2271657 (1251 bp)
Type: Others
Protein ID: NP_390033.2
Location: 2271650..2271982 (333 bp)
Type: Others
Protein ID: NP_390034.1
Location: 2272534..2272890 (357 bp)
Type: Others
Protein ID: NP_390036.1
Location: 2272896..2273363 (468 bp)
Type: Others
Protein ID: NP_390037.1
Location: 2273705..2273884 (180 bp)
Type: Antitoxin
Protein ID: -
Location: 2273989..2274522 (534 bp)
Type: Others
Protein ID: NP_390038.1
Location: 2274558..2275136 (579 bp)
Type: Others
Protein ID: NP_390039.1
Location: 2275200..2275697 (498 bp)
Type: Others
Protein ID: NP_390040.1
Location: 2275706..2277421 (1716 bp)
Type: Others
Protein ID: NP_390041.2
Location: 2277521..2278078 (558 bp)
Type: Others
Protein ID: NP_390042.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BSU_21480 (BSU21480)2269521..2269691-171NP_390031.1sublancin 168 lantibiotic antimicrobial precursor peptide; SPBeta prophage-
BSU_21490 (BSU21490)2269988..2270305-318NP_390032.1protein of immunity to sublancin-
BSU_21500 (BSU21500)2270407..2271657-1251NP_390033.2lesion bypass phage DNA polymerase; phage SPbeta-
BSU_21510 (BSU21510)2271650..2271982-333NP_390034.1conserved hypothetical protein; phage SPbeta-
BSU_21520 (BSU21520)2272156..2272491+336NP_390035.1conserved phage protein of unknown function; phage SPbeta-
BSU_21530 (BSU21530)2272534..2272890-357NP_390036.1conserved protein of unknown function; phage SPbeta-
BSU_21540 (BSU21540)2272896..2273363-468NP_390037.1conserved exported protein of unknown function; SPbeta phage-
BSU_21546 (BSU21546)2273594..2273710+117YP_009513970.1phage toxin; type I toxin-antitoxin systemToxin
-2273705..2273884-180--Antitoxin
BSU_21550 (BSU21550)2273989..2274522-534NP_390038.1putative N-acetyltransferase; phage SPbeta-
BSU_21560 (BSU21560)2274558..2275136-579NP_390039.1conserved protein of unknown function; phage SPbeta-
BSU_21570 (BSU21570)2275200..2275697-498NP_390040.1conserved protein of unknown function; phage SPbeta-
BSU_21580 (BSU21580)2275706..2277421-1716NP_390041.2putative RNase; phage SPbeta-
BSU_21590 (BSU21590)2277521..2278078-558NP_390042.1conserved protein of unknown function; phage SPbeta-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--2151626..2286408134782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T6321 YP_009513970.1 NC_000964:2273594-2273710 [Bacillus subtilis subsp. subtilis str. 168]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T6321 NC_000964:2273594-2273710 [Bacillus subtilis subsp. subtilis str. 168]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 180 bp

>AT6321 NC_000964:c2273884-2273705 [Bacillus subtilis subsp. subtilis str. 168]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T10205Enterococcus faecalis V583

37.838

97.368

0.368

T6278Enterococcus faecalis V583

50

66.667

0.333

T10204Enterococcus faecalis V583

29.73

100

0.324
Showing 1 to 3 of 3 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

Download structure file

References

(1) Natalie Jahn et al. (2013) One antitoxin--two functions: SR4 controls toxin mRNA decay and translation. Nucleic Acids Research 41(21):9870-80. [PubMed:23969414] experimental

(2) Sylvain Durand et al. (2012) Type I toxin-antitoxin systems in Bacillus subtilis. RNA Biology 9(12):1491-7. [PubMed:23059907] experimental


experimental experimental literature