Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2266895..2267185 Replicon chromosome
Accession NZ_CP050532
Organism Bacillus subtilis subsp. subtilis str. SMY

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag HCN55_RS11655 Protein ID WP_009967548.1
Coordinates 2266895..2267011 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2267006..2267185 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCN55_RS11620 2262822..2262992 - 171 WP_009967544.1 bacteriocin sublancin-168 -
HCN55_RS11625 2263289..2263606 - 318 WP_009967545.1 sublancin immunity protein SunI -
HCN55_RS11630 2263708..2264958 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
HCN55_RS11635 2264951..2265283 - 333 WP_004398710.1 YolD-like family protein -
HCN55_RS11640 2265457..2265792 + 336 WP_004399073.1 hypothetical protein -
HCN55_RS11645 2265835..2266191 - 357 WP_004398595.1 hypothetical protein -
HCN55_RS11650 2266197..2266664 - 468 WP_003246138.1 YolA family protein -
HCN55_RS11655 2266895..2267011 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- 2267006..2267185 - 180 NuclAT_1 - Antitoxin
- 2267006..2267185 - 180 NuclAT_1 - Antitoxin
- 2267006..2267185 - 180 NuclAT_1 - Antitoxin
- 2267006..2267185 - 180 NuclAT_1 - Antitoxin
HCN55_RS11660 2267290..2267823 - 534 WP_004399156.1 GNAT family N-acetyltransferase -
HCN55_RS11665 2267859..2268437 - 579 WP_004399123.1 SMI1/KNR4 family protein -
HCN55_RS11670 2268501..2268998 - 498 WP_003246188.1 SMI1/KNR4 family protein -
HCN55_RS11675 2269007..2270722 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
HCN55_RS11680 2270822..2271379 - 558 WP_003246042.1 SMI1/KNR4 family protein -
HCN55_RS11685 2271463..2271648 + 186 WP_003245951.1 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2144927..2279709 134782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-38)


Sequences


Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T153034 WP_009967548.1 NZ_CP050532:2266895-2267011 [Bacillus subtilis subsp. subtilis str. SMY]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T153034 NZ_CP066748:2253774-2253877 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 180 bp

>AT153034 NZ_CP050532:c2267185-2267006 [Bacillus subtilis subsp. subtilis str. SMY]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9


Antitoxin

Download structure file

References