Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | yoyJ-SR6/- |
| Location | 2219514..2219843 | Replicon | chromosome |
| Accession | NC_000964 | ||
| Organism | Bacillus subtilis subsp. subtilis str. 168 | ||
Toxin (Protein)
| Gene name | yoyJ | Uniprot ID | C0H439 |
| Locus tag | BSU_20999 | Protein ID | YP_003097750.1 |
| Coordinates | 2219514..2219765 (-) | Length | 84 a.a. |
Antitoxin (RNA)
| Gene name | - | ||
| Locus tag | - | ||
| Coordinates | () |
Genomic Context
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BSU_20950 (BSU20950) | 2214972..2215199 | - | 228 | NP_389978.1 | putative transcriptional regulator, lambda repressor-like; phage SPbeta | - |
| BSU_20960 (BSU20960) | 2215460..2216776 | - | 1317 | NP_389979.1 | conserved protein of unknown function; phage SPbeta | - |
| BSU_20970 (BSU20970) | 2217133..2217639 | - | 507 | NP_389980.1 | conserved protein of unknown function; phage SPbeta | - |
| BSU_20980 (BSU20980) | 2217967..2219199 | - | 1233 | NP_389981.1 | conserved protein of unknown function; phage SPbeta | - |
| BSU_20990 (BSU20990) | 2219281..2219469 | - | 189 | NP_389982.1 | conserved protein of unknown function; phage SPbeta | - |
| BSU_20999 (BSU20999) | 2219514..2219765 | - | 252 | YP_003097750.1 | conserved protein of unknown function (toxin/antitoxin island); phage SPbeta | Toxin |
| BSU_21000 (BSU21000) | 2219784..2219960 | - | 177 | NP_389983.1 | toxin; phage SPbeta | - |
| BSU_21010 (BSU21010) | 2220335..2220946 | - | 612 | NP_389984.1 | putative hydrolase lipoprotein; phage SPbeta | - |
| BSU_21020 (BSU21020) | 2221061..2221387 | - | 327 | NP_389985.1 | putative transcriptional regulator (Xre family); phage SPbeta | - |
| BSU_21030 (BSU21030) | 2222340..2222534 | + | 195 | NP_389986.1 | hypothetical protein; phage SPbeta | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2151626..2286408 | 134782 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9956.96 Da Isoelectric Point: 9.7930
>T6323b YP_003097750.1 NC_000964:c2219765-2219514 [Bacillus subtilis subsp. subtilis str. 168]
MNFSFSSYPYYNMIKHIANMKRFSLWFTHITFIGLFLMFQLIKDYFSSEGQALINTIFVVTCIIAILLWIIYCVFLKLRN
KSH
MNFSFSSYPYYNMIKHIANMKRFSLWFTHITFIGLFLMFQLIKDYFSSEGQALINTIFVVTCIIAILLWIIYCVFLKLRN
KSH
Download Length: 252 bp
>T6323b NC_000964:c2219765-2219514 [Bacillus subtilis subsp. subtilis str. 168]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATCAAAGATTACTTCAGCAGCGAAGGACAGGCGCTAA
TCAACACAATTTTTGTTGTCACATGTATCATTGCCATATTGTTATGGATCATCTATTGTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATCAAAGATTACTTCAGCAGCGAAGGACAGGCGCTAA
TCAACACAATTTTTGTTGTCACATGTATCATTGCCATATTGTTATGGATCATCTATTGTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA
Antitoxin
Download Length: 1 bp
Structures
Toxin
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Source | ID | Structure |
|---|---|---|
| AlphaFold DB | C0H439 |
Antitoxin
Download structure file
References
(1) Celine Reif et al. (2018) Bacillus subtilis Type I antitoxin SR6 Promotes Degradation of Toxin yonT mRNA and Is Required to Prevent Toxic yoyJ Overexpression. Toxins 10(2):74. [PubMed:29414903]