Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2253086..2253376 Replicon chromosome
Accession NZ_CP010314
Organism Bacillus subtilis subsp. subtilis strain 3NA isolate 1970 (Michel and Millet)

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag RP72_RS23305 Protein ID WP_009967548.1
Coordinates 2253086..2253202 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2253197..2253376 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RP72_RS11675 2249013..2249183 - 171 WP_009967544.1 bacteriocin sublancin-168 -
RP72_RS11680 2249480..2249797 - 318 WP_009967545.1 sublancin immunity protein SunI -
RP72_RS11685 2249899..2251149 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
RP72_RS11690 2251142..2251474 - 333 WP_004398710.1 YolD-like family protein -
RP72_RS11695 2251648..2251983 + 336 WP_004399073.1 hypothetical protein -
RP72_RS11700 2252026..2252382 - 357 WP_004398595.1 hypothetical protein -
RP72_RS11705 2252388..2252855 - 468 WP_003246138.1 YolA family protein -
RP72_RS23305 2253086..2253202 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- 2253197..2253376 - 180 NuclAT_1 - Antitoxin
- 2253197..2253376 - 180 NuclAT_1 - Antitoxin
- 2253197..2253376 - 180 NuclAT_1 - Antitoxin
- 2253197..2253376 - 180 NuclAT_1 - Antitoxin
RP72_RS11715 2253481..2254014 - 534 WP_004399156.1 GNAT family N-acetyltransferase -
RP72_RS11720 2254050..2254628 - 579 WP_004399123.1 SMI1/KNR4 family protein -
RP72_RS11725 2254692..2255189 - 498 WP_003246188.1 SMI1/KNR4 family protein -
RP72_RS11730 2255198..2256913 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
RP72_RS11735 2257013..2257570 - 558 WP_003246042.1 SMI1/KNR4 family protein -
RP72_RS22655 2257654..2257839 + 186 WP_003245951.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2131118..2265900 134782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T52005 WP_009967548.1 NZ_CP010314:2253086-2253202 [Bacillus subtilis subsp. subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T52005 NZ_CP010314:2253086-2253202 [Bacillus subtilis subsp. subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 180 bp

>AT52005 NZ_CP010314:c2253376-2253197 [Bacillus subtilis subsp. subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9

Antitoxin

Download structure file

References