Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2253209..2253499 Replicon chromosome
Accession NZ_CP015004
Organism Bacillus subtilis strain SZMC 6179J isolate B23

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag A3772_RS22700 Protein ID WP_009967548.1
Coordinates 2253209..2253325 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2253320..2253499 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3772_RS11660 2249136..2249306 - 171 WP_009967544.1 bacteriocin sublancin-168 -
A3772_RS11665 2249603..2249920 - 318 WP_009967545.1 sublancin immunity protein SunI -
A3772_RS11670 2250022..2251272 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
A3772_RS11675 2251265..2251597 - 333 WP_004398710.1 YolD-like family protein -
A3772_RS11680 2251771..2252106 + 336 WP_004399073.1 hypothetical protein -
A3772_RS11685 2252149..2252505 - 357 WP_004398595.1 hypothetical protein -
A3772_RS11690 2252511..2252978 - 468 WP_003246138.1 YolA family protein -
A3772_RS22700 2253209..2253325 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- 2253320..2253499 - 180 NuclAT_1 - Antitoxin
- 2253320..2253499 - 180 NuclAT_1 - Antitoxin
- 2253320..2253499 - 180 NuclAT_1 - Antitoxin
- 2253320..2253499 - 180 NuclAT_1 - Antitoxin
A3772_RS11700 2253604..2254137 - 534 WP_004399156.1 GNAT family N-acetyltransferase -
A3772_RS11705 2254173..2254751 - 579 WP_004399123.1 SMI1/KNR4 family protein -
A3772_RS11710 2254815..2255312 - 498 WP_003246188.1 SMI1/KNR4 family protein -
A3772_RS11715 2255321..2257036 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
A3772_RS11720 2257136..2257693 - 558 WP_003246042.1 SMI1/KNR4 family protein -
A3772_RS22265 2257777..2257962 + 186 WP_003245951.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2131241..2266023 134782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T62014 WP_009967548.1 NZ_CP015004:2253209-2253325 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T62014 NZ_CP015004:2253209-2253325 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 180 bp

>AT62014 NZ_CP015004:c2253499-2253320 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9

Antitoxin

Download structure file

References