Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) yonT-as-bsrG/-
Location 2215008..2215225 Replicon chromosome
Accession NZ_CP094361
Organism Bacillus subtilis strain NCIB 3610

Toxin (Protein)


Gene name yonT Uniprot ID O31941
Locus tag MQC90_RS11450 Protein ID WP_009967515.1
Coordinates 2215008..2215184 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name as-bsrG
Locus tag -
Coordinates 2215125..2215225 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQC90_RS11420 (2210196) 2210196..2210423 - 228 WP_004399298.1 helix-turn-helix transcriptional regulator -
MQC90_RS11425 (2210684) 2210684..2212000 - 1317 WP_004399369.1 hypothetical protein -
MQC90_RS11430 (2212357) 2212357..2212863 - 507 WP_004399486.1 hypothetical protein -
MQC90_RS11435 (2213191) 2213191..2214423 - 1233 WP_004399445.1 hypothetical protein -
MQC90_RS11440 (2214505) 2214505..2214693 - 189 WP_004399547.1 hypothetical protein -
MQC90_RS11445 (2214738) 2214738..2214989 - 252 WP_010886546.1 hypothetical protein -
MQC90_RS11450 (2215008) 2215008..2215184 - 177 WP_009967515.1 hypothetical protein Toxin
- (2215125) 2215125..2215225 + 101 NuclAT_2 - Antitoxin
- (2215125) 2215125..2215225 + 101 NuclAT_2 - Antitoxin
- (2215125) 2215125..2215225 + 101 NuclAT_2 - Antitoxin
- (2215125) 2215125..2215225 + 101 NuclAT_2 - Antitoxin
MQC90_RS11455 (2215559) 2215559..2216170 - 612 WP_009967516.1 lipoprotein -
MQC90_RS11460 (2216285) 2216285..2216611 - 327 WP_009967517.1 helix-turn-helix transcriptional regulator -
MQC90_RS11465 (2217564) 2217564..2217758 + 195 WP_004399291.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2146850..2307109 160259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6882.45 Da        Isoelectric Point: 12.8833

>T239793 WP_009967515.1 NZ_CP094361:c2215184-2215008 [Bacillus subtilis]
VLEKMGIVVAFLISLTVLTINSLTIVEKVRNLKNGTSKKKKRIRKRLRPKRQRQRIRR

Download         Length: 177 bp

>T239793 NZ_LS483321:1614635-1614970 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 101 bp

>AT239793 NZ_CP094361:2215125-2215225 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCATTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB O31941

Antitoxin

Download structure file

References