Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2239690..2239980 Replicon chromosome
Accession NZ_AP024625
Organism Bacillus subtilis strain BEST3109

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag BsBEST3145_RS11510 Protein ID WP_009967548.1
Coordinates 2239690..2239806 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2239801..2239980 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BsBEST3145_RS11475 (2235617) 2235617..2235787 - 171 WP_009967544.1 bacteriocin sublancin-168 -
BsBEST3145_RS11480 (2236084) 2236084..2236401 - 318 WP_009967545.1 sublancin immunity protein SunI -
BsBEST3145_RS11485 (2236503) 2236503..2237753 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
BsBEST3145_RS11490 (2237746) 2237746..2238078 - 333 WP_004398710.1 YolD-like family protein -
BsBEST3145_RS11495 (2238252) 2238252..2238587 + 336 WP_004399073.1 hypothetical protein -
BsBEST3145_RS11500 (2238630) 2238630..2238986 - 357 WP_004398595.1 hypothetical protein -
BsBEST3145_RS11505 (2238992) 2238992..2239459 - 468 WP_003246138.1 YolA family protein -
BsBEST3145_RS11510 (2239690) 2239690..2239806 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- (2239801) 2239801..2239980 - 180 NuclAT_1 - Antitoxin
- (2239801) 2239801..2239980 - 180 NuclAT_1 - Antitoxin
- (2239801) 2239801..2239980 - 180 NuclAT_1 - Antitoxin
- (2239801) 2239801..2239980 - 180 NuclAT_1 - Antitoxin
BsBEST3145_RS11515 (2240085) 2240085..2240618 - 534 WP_004399156.1 GNAT family protein -
BsBEST3145_RS11520 (2240654) 2240654..2241232 - 579 WP_004399123.1 SMI1/KNR4 family protein -
BsBEST3145_RS11525 (2241296) 2241296..2241793 - 498 WP_003246188.1 SMI1/KNR4 family protein -
BsBEST3145_RS11530 (2241802) 2241802..2243517 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
BsBEST3145_RS11535 (2243617) 2243617..2244174 - 558 WP_003246042.1 SMI1/KNR4 family protein -
BsBEST3145_RS11540 (2244309) 2244309..2244443 + 135 WP_234047931.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2117724..2266751 149027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T39068 WP_009967548.1 NZ_AP024625:2239690-2239806 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T39068 NZ_AP024625:2239690-2239806 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 180 bp

>AT39068 NZ_AP024625:c2239980-2239801 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9

Antitoxin

Download structure file

References