Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2245809..2246099 Replicon chromosome
Accession NZ_AP024627
Organism Bacillus subtilis strain BEST3136

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag K6J86_RS11515 Protein ID WP_009967548.1
Coordinates 2245809..2245925 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2245920..2246099 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J86_RS11480 (2241736) 2241736..2241906 - 171 WP_009967544.1 bacteriocin sublancin-168 -
K6J86_RS11485 (2242203) 2242203..2242520 - 318 WP_009967545.1 sublancin immunity protein SunI -
K6J86_RS11490 (2242622) 2242622..2243872 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
K6J86_RS11495 (2243865) 2243865..2244197 - 333 WP_004398710.1 YolD-like family protein -
K6J86_RS11500 (2244371) 2244371..2244706 + 336 WP_004399073.1 hypothetical protein -
K6J86_RS11505 (2244749) 2244749..2245105 - 357 WP_004398595.1 hypothetical protein -
K6J86_RS11510 (2245111) 2245111..2245578 - 468 WP_003246138.1 YolA family protein -
K6J86_RS11515 (2245809) 2245809..2245925 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- (2245920) 2245920..2246099 - 180 NuclAT_1 - Antitoxin
- (2245920) 2245920..2246099 - 180 NuclAT_1 - Antitoxin
- (2245920) 2245920..2246099 - 180 NuclAT_1 - Antitoxin
- (2245920) 2245920..2246099 - 180 NuclAT_1 - Antitoxin
K6J86_RS11520 (2246204) 2246204..2246737 - 534 WP_004399156.1 GNAT family protein -
K6J86_RS11525 (2246773) 2246773..2247351 - 579 WP_004399123.1 SMI1/KNR4 family protein -
K6J86_RS11530 (2247415) 2247415..2247912 - 498 WP_003246188.1 SMI1/KNR4 family protein -
K6J86_RS11535 (2247921) 2247921..2249636 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
K6J86_RS11540 (2249736) 2249736..2250293 - 558 WP_003246042.1 SMI1/KNR4 family protein -
K6J86_RS11545 (2250428) 2250428..2250562 + 135 WP_234047931.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2123843..2258623 134780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T39114 WP_009967548.1 NZ_AP024627:2245809-2245925 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T39114 NZ_AP024627:2245809-2245925 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 180 bp

>AT39114 NZ_AP024627:c2246099-2245920 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9

Antitoxin

Download structure file

References