39137

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2245372..2245662 Replicon chromosome
Accession NZ_AP024628
Organism Bacillus subtilis strain BEST3145

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag K6K00_RS11475 Protein ID WP_009967548.1
Coordinates 2245372..2245488 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2245483..2245662 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K00_RS11440 (2241299) 2241299..2241469 - 171 WP_009967544.1 bacteriocin sublancin-168 -
K6K00_RS11445 (2241766) 2241766..2242083 - 318 WP_009967545.1 sublancin immunity protein SunI -
K6K00_RS11450 (2242185) 2242185..2243435 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
K6K00_RS11455 (2243428) 2243428..2243760 - 333 WP_004398710.1 YolD-like family protein -
K6K00_RS11460 (2243934) 2243934..2244269 + 336 WP_004399073.1 hypothetical protein -
K6K00_RS11465 (2244312) 2244312..2244668 - 357 WP_004398595.1 hypothetical protein -
K6K00_RS11470 (2244674) 2244674..2245141 - 468 WP_003246138.1 YolA family protein -
K6K00_RS11475 (2245372) 2245372..2245488 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- (2245483) 2245483..2245662 - 180 NuclAT_1 - Antitoxin
- (2245483) 2245483..2245662 - 180 NuclAT_1 - Antitoxin
- (2245483) 2245483..2245662 - 180 NuclAT_1 - Antitoxin
- (2245483) 2245483..2245662 - 180 NuclAT_1 - Antitoxin
K6K00_RS11480 (2245767) 2245767..2246300 - 534 WP_004399156.1 GNAT family protein -
K6K00_RS11485 (2246336) 2246336..2246914 - 579 WP_004399123.1 SMI1/KNR4 family protein -
K6K00_RS11490 (2246978) 2246978..2247475 - 498 WP_003246188.1 SMI1/KNR4 family protein -
K6K00_RS11495 (2247484) 2247484..2249199 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
K6K00_RS11500 (2249299) 2249299..2249856 - 558 WP_003246042.1 SMI1/KNR4 family protein -
K6K00_RS11505 (2249991) 2249991..2250125 + 135 WP_234047931.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2123406..2258186 134780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T39137 WP_009967548.1 NZ_AP024628:2245372-2245488 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T39137 NZ_AP024628:2245372-2245488 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 180 bp

>AT39137 NZ_AP024628:c2245662-2245483 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9

Antitoxin

Download structure file

References