Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2239428..2239718 Replicon chromosome
Accession NZ_AP024626
Organism Bacillus subtilis strain BEST3125

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag K6K02_RS11490 Protein ID WP_009967548.1
Coordinates 2239428..2239544 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2239539..2239718 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K02_RS11455 (2235355) 2235355..2235525 - 171 WP_009967544.1 bacteriocin sublancin-168 -
K6K02_RS11460 (2235822) 2235822..2236139 - 318 WP_009967545.1 sublancin immunity protein SunI -
K6K02_RS11465 (2236241) 2236241..2237491 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
K6K02_RS11470 (2237484) 2237484..2237816 - 333 WP_004398710.1 YolD-like family protein -
K6K02_RS11475 (2237990) 2237990..2238325 + 336 WP_004399073.1 hypothetical protein -
K6K02_RS11480 (2238368) 2238368..2238724 - 357 WP_004398595.1 hypothetical protein -
K6K02_RS11485 (2238730) 2238730..2239197 - 468 WP_003246138.1 YolA family protein -
K6K02_RS11490 (2239428) 2239428..2239544 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- (2239539) 2239539..2239718 - 180 NuclAT_1 - Antitoxin
- (2239539) 2239539..2239718 - 180 NuclAT_1 - Antitoxin
- (2239539) 2239539..2239718 - 180 NuclAT_1 - Antitoxin
- (2239539) 2239539..2239718 - 180 NuclAT_1 - Antitoxin
K6K02_RS11495 (2239823) 2239823..2240356 - 534 WP_004399156.1 GNAT family protein -
K6K02_RS11500 (2240392) 2240392..2240970 - 579 WP_004399123.1 SMI1/KNR4 family protein -
K6K02_RS11505 (2241034) 2241034..2241531 - 498 WP_003246188.1 SMI1/KNR4 family protein -
K6K02_RS11510 (2241540) 2241540..2243255 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
K6K02_RS11515 (2243355) 2243355..2243912 - 558 WP_003246042.1 SMI1/KNR4 family protein -
K6K02_RS11520 (2244047) 2244047..2244181 + 135 WP_234047931.1 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2117462..2266489 149027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-38)


Sequences


Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T39091 WP_009967548.1 NZ_AP024626:2239428-2239544 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T39091 NZ_AP024626:2239428-2239544 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 180 bp

>AT39091 NZ_AP024626:c2239718-2239539 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9


Antitoxin

Download structure file

References