Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2273598..2273888 Replicon chromosome
Accession NZ_CP058242
Organism Bacillus subtilis strain SP1

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag HWV68_RS11685 Protein ID WP_009967548.1
Coordinates 2273598..2273714 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2273709..2273888 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV68_RS11650 2269525..2269695 - 171 WP_009967544.1 bacteriocin sublancin-168 -
HWV68_RS11655 2269992..2270309 - 318 WP_009967545.1 sublancin immunity protein SunI -
HWV68_RS11660 2270411..2271661 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
HWV68_RS11665 2271654..2271986 - 333 WP_004398710.1 YolD-like family protein -
HWV68_RS11670 2272160..2272495 + 336 WP_004399073.1 hypothetical protein -
HWV68_RS11675 2272538..2272894 - 357 WP_004398595.1 hypothetical protein -
HWV68_RS11680 2272900..2273367 - 468 WP_003246138.1 YolA family protein -
HWV68_RS11685 2273598..2273714 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- 2273709..2273888 - 180 NuclAT_1 - Antitoxin
- 2273709..2273888 - 180 NuclAT_1 - Antitoxin
- 2273709..2273888 - 180 NuclAT_1 - Antitoxin
- 2273709..2273888 - 180 NuclAT_1 - Antitoxin
HWV68_RS11690 2273993..2274526 - 534 WP_004399156.1 GNAT family N-acetyltransferase -
HWV68_RS11695 2274562..2275140 - 579 WP_004399123.1 SMI1/KNR4 family protein -
HWV68_RS11700 2275204..2275701 - 498 WP_003246188.1 SMI1/KNR4 family protein -
HWV68_RS11705 2275710..2277425 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
HWV68_RS11710 2277525..2278082 - 558 WP_003246042.1 SMI1/KNR4 family protein -
HWV68_RS11715 2278166..2278351 + 186 WP_003245951.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2151630..2286412 134782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T166394 WP_009967548.1 NZ_CP058242:2273598-2273714 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T166394 NZ_CP074143:5117021-5117356 [Serratia sp. JSRIV002]
ATGAAGACCATGAACAAACTCCCCCACACCCCGTCCAATGCCAGTCCCGCCTTTCTCGAATACCAGCAACTGCTTGCCTG
GTTGCTGGCTCACTGTTACGGCCTGGAGCTCAATGACACGCCGTATCACGACGATCAGGCGATTACCCAACAGATTGAGT
ATGGCGTCACGGTACGCGAAACCGTCAACGAACTGGTGGAGAAATTTGACCTAGTACGTATTGACCGACCTGGATTCAGC
CTTATGGCACAAGATCCGACTTTGAGCGCCGGTGACATGCTCTGCGCCCGCAGCGCACGGGGATTACGCAGCCCGGTGAT
TCGCCGCCTGGCTTGA

Antitoxin


Download         Length: 180 bp

>AT166394 NZ_CP058242:c2273888-2273709 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9

Antitoxin

Download structure file

References