Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) bsrG-as-bsrH/-
Location 2242194..2242484 Replicon chromosome
Accession NZ_AP024623
Organism Bacillus subtilis strain BEST3102

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag K6J99_RS11515 Protein ID WP_009967548.1
Coordinates 2242194..2242310 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2242305..2242484 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J99_RS11480 (2238121) 2238121..2238291 - 171 WP_009967544.1 bacteriocin sublancin-168 -
K6J99_RS11485 (2238588) 2238588..2238905 - 318 WP_009967545.1 sublancin immunity protein SunI -
K6J99_RS11490 (2239007) 2239007..2240257 - 1251 WP_004398504.1 UV-damage repair protein uvrX -
K6J99_RS11495 (2240250) 2240250..2240582 - 333 WP_004398710.1 YolD-like family protein -
K6J99_RS11500 (2240756) 2240756..2241091 + 336 WP_004399073.1 hypothetical protein -
K6J99_RS11505 (2241134) 2241134..2241490 - 357 WP_004398595.1 hypothetical protein -
K6J99_RS11510 (2241496) 2241496..2241963 - 468 WP_003246138.1 YolA family protein -
K6J99_RS11515 (2242194) 2242194..2242310 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- (2242305) 2242305..2242484 - 180 NuclAT_1 - Antitoxin
- (2242305) 2242305..2242484 - 180 NuclAT_1 - Antitoxin
- (2242305) 2242305..2242484 - 180 NuclAT_1 - Antitoxin
- (2242305) 2242305..2242484 - 180 NuclAT_1 - Antitoxin
K6J99_RS11520 (2242589) 2242589..2243122 - 534 WP_004399156.1 GNAT family protein -
K6J99_RS11525 (2243158) 2243158..2243736 - 579 WP_004399123.1 SMI1/KNR4 family protein -
K6J99_RS11530 (2243800) 2243800..2244297 - 498 WP_003246188.1 SMI1/KNR4 family protein -
K6J99_RS11535 (2244306) 2244306..2246021 - 1716 WP_004398855.1 ribonuclease YeeF family protein -
K6J99_RS11540 (2246121) 2246121..2246678 - 558 WP_003246042.1 SMI1/KNR4 family protein -
K6J99_RS11545 (2246813) 2246813..2246947 + 135 WP_234047931.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2120228..2255008 134780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T39022 WP_009967548.1 NZ_AP024623:2242194-2242310 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

>T39022 NZ_AP024623:2242194-2242310 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 180 bp

>AT39022 NZ_AP024623:c2242484-2242305 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9

Antitoxin

Download structure file

References