Detailed information of TA system TA039022

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-as-bsrH/-
• Location: 2242194..2242484
• Replicon: chromosome
• Accession: NZ_AP024623
• Organism: Bacillus subtilis strain BEST3102

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: K6J99_RS11515
• Protein ID: WP_009967548.1
• Coordinates: 2242194..2242310 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	as-bsrH
Locus tag	-
Coordinates	2242305..2242484 (-)

Genomic Context

Location: 2240756..2241091 (336 bp)
Type: Others
Protein ID: WP_004399073.1

Location: 2242194..2242310 (117 bp)
Type: Toxin
Protein ID: WP_009967548.1

Location: 2246813..2246947 (135 bp)
Type: Others
Protein ID: WP_234047931.1

Location: 2238121..2238291 (171 bp)
Type: Others
Protein ID: WP_009967544.1

Location: 2238588..2238905 (318 bp)
Type: Others
Protein ID: WP_009967545.1

Location: 2239007..2240257 (1251 bp)
Type: Others
Protein ID: WP_004398504.1

Location: 2240250..2240582 (333 bp)
Type: Others
Protein ID: WP_004398710.1

Location: 2241134..2241490 (357 bp)
Type: Others
Protein ID: WP_004398595.1

Location: 2241496..2241963 (468 bp)
Type: Others
Protein ID: WP_003246138.1

Location: 2242305..2242484 (180 bp)
Type: Antitoxin
Protein ID: NuclAT_1

Location: 2242305..2242484 (180 bp)
Type: Antitoxin
Protein ID: NuclAT_1

Location: 2242305..2242484 (180 bp)
Type: Antitoxin
Protein ID: NuclAT_1

Location: 2242305..2242484 (180 bp)
Type: Antitoxin
Protein ID: NuclAT_1

Location: 2242589..2243122 (534 bp)
Type: Others
Protein ID: WP_004399156.1

Location: 2243158..2243736 (579 bp)
Type: Others
Protein ID: WP_004399123.1

Location: 2243800..2244297 (498 bp)
Type: Others
Protein ID: WP_003246188.1

Location: 2244306..2246021 (1716 bp)
Type: Others
Protein ID: WP_004398855.1

Location: 2246121..2246678 (558 bp)
Type: Others
Protein ID: WP_003246042.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J99_RS11480 (2238121)	2238121..2238291	-	171	WP_009967544.1	bacteriocin sublancin-168	-
K6J99_RS11485 (2238588)	2238588..2238905	-	318	WP_009967545.1	sublancin immunity protein SunI	-
K6J99_RS11490 (2239007)	2239007..2240257	-	1251	WP_004398504.1	UV-damage repair protein uvrX	-
K6J99_RS11495 (2240250)	2240250..2240582	-	333	WP_004398710.1	YolD-like family protein	-
K6J99_RS11500 (2240756)	2240756..2241091	+	336	WP_004399073.1	hypothetical protein	-
K6J99_RS11505 (2241134)	2241134..2241490	-	357	WP_004398595.1	hypothetical protein	-
K6J99_RS11510 (2241496)	2241496..2241963	-	468	WP_003246138.1	YolA family protein	-
K6J99_RS11515 (2242194)	2242194..2242310	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
- (2242305)	2242305..2242484	-	180	NuclAT_1	-	Antitoxin
- (2242305)	2242305..2242484	-	180	NuclAT_1	-	Antitoxin
- (2242305)	2242305..2242484	-	180	NuclAT_1	-	Antitoxin
- (2242305)	2242305..2242484	-	180	NuclAT_1	-	Antitoxin
K6J99_RS11520 (2242589)	2242589..2243122	-	534	WP_004399156.1	GNAT family protein	-
K6J99_RS11525 (2243158)	2243158..2243736	-	579	WP_004399123.1	SMI1/KNR4 family protein	-
K6J99_RS11530 (2243800)	2243800..2244297	-	498	WP_003246188.1	SMI1/KNR4 family protein	-
K6J99_RS11535 (2244306)	2244306..2246021	-	1716	WP_004398855.1	ribonuclease YeeF family protein	-
K6J99_RS11540 (2246121)	2246121..2246678	-	558	WP_003246042.1	SMI1/KNR4 family protein	-
K6J99_RS11545 (2246813)	2246813..2246947	+	135	WP_234047931.1	transposase	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000964 Bacillus subtilis subsp. subtilis str. 168 Prophage TA006323, TA006321, TA06323b, TA020252 2151626..2286408 0	inside	Prophage	-	-	2120228..2255008	134780

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T39022 WP_009967548.1 NZ_AP024623:2242194-2242310 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T39022 NZ_AP024623:2242194-2242310 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin

Nucleotide

• Length: 180 bp

>AT39022 NZ_AP024623:c2242484-2242305 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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• AlphaFold DB: A0A7Z7EVU9

Antitoxin