Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-ratA/- |
| Location | 3123490..3123823 | Replicon | chromosome |
| Accession | NC_004668 | ||
| Organism | Enterococcus faecalis V583 | ||
| T1TAdb ID | TA05739 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q82Z30 |
| Locus tag | EF_RS15355 | Protein ID | WP_002387585.1 |
| Coordinates | 3123490..3123633 (+) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | ratA | ||
| Locus tag | - | ||
| Coordinates | 3123565..3123823 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EF_RS16860 | 3118842..3118946 | + | 105 | WP_021164545.1 | putative holin-like toxin | - |
| EF_RS15350 (EF3248) | 3119136..3122894 | - | 3759 | WP_010706868.1 | WxL domain-containing protein | - |
| EF_RS15355 (EF3249) | 3123490..3123633 | + | 144 | WP_002387585.1 | putative holin-like toxin | Toxin |
| - | 3123565..3123823 | - | 259 | - | - | Antitoxin |
| EF_RS15360 | 3123823..3126881 | - | 3059 | Protein_3029 | WxL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5244.37 Da Isoelectric Point: 10.5719
>T10205 WP_002387585.1 NC_004668:3123490-3123633 [Enterococcus faecalis V583]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK
Download Length: 144 bp
>T10205 NC_004668:3123490-3123633 [Enterococcus faecalis V583]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA
Antitoxin
Download Length: 259 bp
>AT10205 NC_004668:c3123823-3123565 [Enterococcus faecalis V583]
AAATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCGATTTTGTTACAA
AAAATAACCGTACTCAGTCAAAGTAAACGGTTATTTTTTCTTGTCTTCTTTAACAACCTTTAGGATTCCGAAGATTAAAG
TCGCGATAAAAGAACCGAA
AAATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCGATTTTGTTACAA
AAAATAACCGTACTCAGTCAAAGTAAACGGTTATTTTTTCTTGTCTTCTTTAACAACCTTTAGGATTCCGAAGATTAAAG
TCGCGATAAAAGAACCGAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10202 | Enterococcus faecalis V583 |
60.606 |
100 |
0.606 |
| T10203 | Enterococcus faecalis V583 |
57.576 |
100 |
0.576 |
| T10207 | Enterococcus faecalis V583 |
46.154 |
100 |
0.462 |
| T10049 | Staphylococcus aureus strain HG003 isolate RN1 Scaffold_9 |
45.714 |
100 |
0.457 |
| T10204 | Enterococcus faecalis V583 |
41.176 |
100 |
0.412 |
| T10025 | Staphylococcus aureus subsp. aureus N315 |
40 |
100 |
0.4 |
| T10200 | Bacillus subtilis subsp. subtilis str. 168 |
44.444 |
90 |
0.4 |
| T10206 | Enterococcus faecalis V583 |
44.118 |
89.474 |
0.395 |
| T10201 | Bacillus subtilis subsp. subtilis str. 168 |
52.381 |
72.414 |
0.379 |
| T6321 | Bacillus subtilis subsp. subtilis str. 168 |
37.838 |
97.368 |
0.368 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Elizabeth M Fozo et al. (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Research 38(11):3743-59. [PubMed:20156992]