Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type I Classification (family/domain) bsrH-as-bsrH/-
Location 2678799..2679077 Replicon chromosome
Accession NC_000964
Organism Bacillus subtilis subsp. subtilis str. 168
T1TAdb ID TA04736

Toxin (Protein)


Gene name bsrH Uniprot ID -
Locus tag BSU_26055 Protein ID YP_009513980.1
Coordinates 2678799..2678888 (+) Length 30 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2678876..2679077 (-)

Genomic Context

BSU_26050BSU_26055--BSU_26060BSU_26075BSU_26089BSU_26090BSU_26100BSU_26110BSU_26120BSU_26130
Location: 2678240..2678419 (180 bp)
Type: Others
Protein ID: NP_390482.1
Location: 2678799..2678888 (90 bp)
Type: Toxin
Protein ID: YP_009513980.1
Location: 2678876..2679077 (202 bp)
Type: Antitoxin
Protein ID: -
Location: 2679142..2679585 (444 bp)
Type: Others
Protein ID: NP_390483.2
Location: 2679588..2680988 (1401 bp)
Type: Others
Protein ID: NP_390485.2
Location: 2680989..2681180 (192 bp)
Type: Others
Protein ID: YP_003097763.1
Location: 2681177..2681614 (438 bp)
Type: Others
Protein ID: NP_390486.2
Location: 2681627..2682130 (504 bp)
Type: Others
Protein ID: NP_390487.1
Location: 2682127..2682489 (363 bp)
Type: Others
Protein ID: NP_390488.1
Location: 2682486..2682881 (396 bp)
Type: Others
Protein ID: NP_390489.2
Location: 2682885..2683196 (312 bp)
Type: Others
Protein ID: NP_390490.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BSU_26050 (BSU26050)2678240..2678419+180NP_390482.1toxic peptide of toxin-antitoxin system; skin element-
BSU_26055 (BSU26055)2678799..2678888+90YP_009513980.1skin region; type I toxinToxin
-2678876..2679077-202--Antitoxin
BSU_26060 (BSU26060)2679142..2679585-444NP_390483.2putative tail tube protein; skin element-
BSU_26075 (BSU26075)2679588..2680988-1401NP_390485.2putative phage tail sheath protein; skin element-
BSU_26089 (BSU26089)2680989..2681180-192YP_003097763.1conserved phage protein of unknown function; skin element-
BSU_26090 (BSU26090)2681177..2681614-438NP_390486.2conserved phage protein of unknown function; skin element-
BSU_26100 (BSU26100)2681627..2682130-504NP_390487.1putative phage tail component; skin element-
BSU_26110 (BSU26110)2682127..2682489-363NP_390488.1conserved phage protein of unknown function; skin element-
BSU_26120 (BSU26120)2682486..2682881-396NP_390489.2conserved phage protein of unknown function; skin element-
BSU_26130 (BSU26130)2682885..2683196-312NP_390490.1hypothetical protein; skin element-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--2645490..269924353753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(4-28)


Sequences

Toxin        


Download         Length: 30 a.a.        Molecular weight: 3317.16 Da        Isoelectric Point: 10.6389

>T10201 YP_009513980.1 NC_000964:2678799-2678888 [Bacillus subtilis subsp. subtilis str. 168]
MHVSTFQALMLMLAFGSFIIALLTYIKKK

Download         Length: 90 bp

>T10201 NC_000964:2678799-2678888 [Bacillus subtilis subsp. subtilis str. 168]
ATGCACGTGTCAACATTTCAAGCATTAATGCTTATGCTTGCTTTCGGGTCATTTATAATTGCCCTGTTGACTTATATAAA
GAAGAAATAG

Antitoxin


Download         Length: 202 bp

>AT10201 NC_000964:c2679077-2678876 [Bacillus subtilis subsp. subtilis str. 168]
TTAGAAGTAATTCAACCGTACCAAATGGAAACATGTATTTCTTTCAAAAGAAATGCATAAAATAAAAGAGACCCGGTTGC
CGCCGGGTCAGTATAAATGTTGGCCCATCAAGAGGGCTGGCTTAACAACTTCATGAAAGTATTTAGGATAGACTTTACCC
TTTTACTTTGCCGAGCTCAAGGGGTGGGTCTATTTCTTCTTT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T10200Bacillus subtilis subsp. subtilis str. 168

92

86.207

0.793

T6278Enterococcus faecalis V583

40.741

100

0.407

T10205Enterococcus faecalis V583

52.381

72.414

0.379

T10207Enterococcus faecalis V583

60

57.692

0.346

T10204Enterococcus faecalis V583

40

86.207

0.345

T10049Staphylococcus aureus strain HG003 isolate RN1 Scaffold_9

47.619

72.414

0.345

T10146Staphylococcus aureus strain HG003 isolate RN1 Scaffold_5

52.941

58.621

0.31

T6360Staphylococcus aureus subsp. aureus N315

52.941

58.621

0.31
Showing 1 to 8 of 8 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

Download structure file

References

(1) Sylvain Durand et al. (2012) Type I toxin-antitoxin systems in Bacillus subtilis. RNA Biology 9(12):1491-7. [PubMed:23059907] experimental


experimental experimental literature