Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type I Classification (family/domain) bsrH-as-bsrH/-
Location 2678799..2679077 Replicon chromosome
Accession NC_000964
Organism Bacillus subtilis subsp. subtilis str. 168
T1TAdb ID TA04736

Toxin (Protein)


Gene name bsrH Uniprot ID -
Locus tag BSU_26055 Protein ID YP_009513980.1
Coordinates 2678799..2678888 (+) Length 30 a.a.

Antitoxin (RNA)


Gene name as-bsrH
Locus tag -
Coordinates 2678876..2679077 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSU_26050 (BSU26050) 2678240..2678419 + 180 NP_390482.1 toxic peptide of toxin-antitoxin system; skin element -
BSU_26055 (BSU26055) 2678799..2678888 + 90 YP_009513980.1 skin region; type I toxin Toxin
- 2678876..2679077 - 202 - - Antitoxin
BSU_26060 (BSU26060) 2679142..2679585 - 444 NP_390483.2 putative tail tube protein; skin element -
BSU_26075 (BSU26075) 2679588..2680988 - 1401 NP_390485.2 putative phage tail sheath protein; skin element -
BSU_26089 (BSU26089) 2680989..2681180 - 192 YP_003097763.1 conserved phage protein of unknown function; skin element -
BSU_26090 (BSU26090) 2681177..2681614 - 438 NP_390486.2 conserved phage protein of unknown function; skin element -
BSU_26100 (BSU26100) 2681627..2682130 - 504 NP_390487.1 putative phage tail component; skin element -
BSU_26110 (BSU26110) 2682127..2682489 - 363 NP_390488.1 conserved phage protein of unknown function; skin element -
BSU_26120 (BSU26120) 2682486..2682881 - 396 NP_390489.2 conserved phage protein of unknown function; skin element -
BSU_26130 (BSU26130) 2682885..2683196 - 312 NP_390490.1 hypothetical protein; skin element -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2645490..2699243 53753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(4-28)


Sequences

Toxin        


Download         Length: 30 a.a.        Molecular weight: 3317.16 Da        Isoelectric Point: 10.6389

>T10201 YP_009513980.1 NC_000964:2678799-2678888 [Bacillus subtilis subsp. subtilis str. 168]
MHVSTFQALMLMLAFGSFIIALLTYIKKK

Download         Length: 90 bp

>T10201 NC_000964:2678799-2678888 [Bacillus subtilis subsp. subtilis str. 168]
ATGCACGTGTCAACATTTCAAGCATTAATGCTTATGCTTGCTTTCGGGTCATTTATAATTGCCCTGTTGACTTATATAAA
GAAGAAATAG

Antitoxin


Download         Length: 202 bp

>AT10201 NC_000964:c2679077-2678876 [Bacillus subtilis subsp. subtilis str. 168]
TTAGAAGTAATTCAACCGTACCAAATGGAAACATGTATTTCTTTCAAAAGAAATGCATAAAATAAAAGAGACCCGGTTGC
CGCCGGGTCAGTATAAATGTTGGCCCATCAAGAGGGCTGGCTTAACAACTTCATGAAAGTATTTAGGATAGACTTTACCC
TTTTACTTTGCCGAGCTCAAGGGGTGGGTCTATTTCTTCTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
T10200 Bacillus subtilis subsp. subtilis str. 168

92

86.207

0.793
T6278 Enterococcus faecalis V583

40.741

100

0.407
T10205 Enterococcus faecalis V583

52.381

72.414

0.379
T10207 Enterococcus faecalis V583

60

57.692

0.346
T10204 Enterococcus faecalis V583

40

86.207

0.345
T10049 Staphylococcus aureus strain HG003 isolate RN1 Scaffold_9

47.619

72.414

0.345
T10146 Staphylococcus aureus strain HG003 isolate RN1 Scaffold_5

52.941

58.621

0.31
T6360 Staphylococcus aureus subsp. aureus N315

52.941

58.621

0.31

Multiple sequence alignment    


Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References

(1) Sylvain Durand et al. (2012) Type I toxin-antitoxin systems in Bacillus subtilis. RNA Biology 9(12):1491-7. [PubMed:23059907] experimental


experimental experimental literature