Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 4084647..4084972 Replicon chromosome
Accession NZ_CP047325
Organism Bacillus subtilis strain GOT9

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag GSY53_RS21000 Protein ID WP_004398662.1
Coordinates 4084647..4084826 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 4084750..4084972 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSY53_RS20990 4083873..4084010 - 138 WP_003229934.1 hypothetical protein -
GSY53_RS20995 4084052..4084501 - 450 WP_003229933.1 phage portal protein -
GSY53_RS21000 4084647..4084826 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 4084750..4084972 - 223 NuclAT_0 - Antitoxin
- 4084750..4084972 - 223 NuclAT_0 - Antitoxin
- 4084750..4084972 - 223 NuclAT_0 - Antitoxin
- 4084750..4084972 - 223 NuclAT_0 - Antitoxin
GSY53_RS21005 4085206..4085295 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
GSY53_RS21010 4085549..4085992 - 444 WP_003229930.1 phage tail tube protein -
GSY53_RS21015 4085995..4087395 - 1401 WP_003229929.1 phage tail sheath family protein -
GSY53_RS21020 4087396..4087587 - 192 WP_010886574.1 hypothetical protein -
GSY53_RS21025 4087584..4088021 - 438 WP_003229927.1 hypothetical protein -
GSY53_RS21030 4088034..4088537 - 504 WP_003246050.1 HK97 gp10 family phage protein -
GSY53_RS21035 4088534..4088896 - 363 WP_003229925.1 YqbH/XkdH family protein -
GSY53_RS21040 4088893..4089288 - 396 WP_004398566.1 DUF3199 family protein -
GSY53_RS21045 4089292..4089603 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4054160..4116406 62246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T145978 WP_004398662.1 NZ_CP047325:4084647-4084826 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T145978 NZ_CP062713:c5059194-5059021 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 223 bp

>AT145978 NZ_CP047325:c4084972-4084750 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References