Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2477742..2478067 Replicon chromosome
Accession NZ_CP120613
Organism Bacillus subtilis strain DSM 23521

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag P5649_RS12855 Protein ID WP_004398662.1
Coordinates 2477888..2478067 (-) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2477742..2477964 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5649_RS12810 (2473111) 2473111..2473422 + 312 WP_003229923.1 YqbF domain-containing protein -
P5649_RS12815 (2473426) 2473426..2473821 + 396 WP_004398566.1 DUF3199 family protein -
P5649_RS12820 (2473818) 2473818..2474180 + 363 WP_003229925.1 YqbH/XkdH family protein -
P5649_RS12825 (2474177) 2474177..2474680 + 504 WP_003246050.1 HK97 gp10 family phage protein -
P5649_RS12830 (2474693) 2474693..2475130 + 438 WP_003229927.1 hypothetical protein -
P5649_RS12835 (2475127) 2475127..2475318 + 192 WP_010886574.1 hypothetical protein -
P5649_RS12840 (2475319) 2475319..2476719 + 1401 WP_003229929.1 phage tail sheath family protein -
P5649_RS12845 (2476722) 2476722..2477165 + 444 WP_003229930.1 phage tail tube protein -
P5649_RS12850 (2477419) 2477419..2477508 - 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
- (2477742) 2477742..2477964 + 223 NuclAT_0 - Antitoxin
- (2477742) 2477742..2477964 + 223 NuclAT_0 - Antitoxin
- (2477742) 2477742..2477964 + 223 NuclAT_0 - Antitoxin
- (2477742) 2477742..2477964 + 223 NuclAT_0 - Antitoxin
P5649_RS12855 (2477888) 2477888..2478067 - 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
P5649_RS12860 (2478213) 2478213..2478662 + 450 WP_003229933.1 phage portal protein -
P5649_RS12865 (2478704) 2478704..2478841 + 138 WP_003229934.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2448623..2518763 70140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T275251 WP_004398662.1 NZ_CP120613:c2478067-2477888 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

Antitoxin


Download         Length: 223 bp

>AT275251 NZ_CP120613:2477742-2477964 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References