Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2673457..2673782 Replicon chromosome
Accession NZ_CP094361
Organism Bacillus subtilis strain NCIB 3610

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag MQC90_RS14105 Protein ID WP_004398662.1
Coordinates 2673457..2673636 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2673560..2673782 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQC90_RS14095 (2672683) 2672683..2672820 - 138 WP_003229934.1 hypothetical protein -
MQC90_RS14100 (2672862) 2672862..2673311 - 450 WP_003229933.1 phage portal protein -
MQC90_RS14105 (2673457) 2673457..2673636 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2673560) 2673560..2673782 - 223 NuclAT_0 - Antitoxin
- (2673560) 2673560..2673782 - 223 NuclAT_0 - Antitoxin
- (2673560) 2673560..2673782 - 223 NuclAT_0 - Antitoxin
- (2673560) 2673560..2673782 - 223 NuclAT_0 - Antitoxin
MQC90_RS14110 (2674016) 2674016..2674105 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
MQC90_RS14115 (2674359) 2674359..2674802 - 444 WP_003229930.1 phage tail tube protein -
MQC90_RS14120 (2674805) 2674805..2676205 - 1401 WP_003229929.1 phage tail sheath family protein -
MQC90_RS14125 (2676206) 2676206..2676397 - 192 WP_010886574.1 hypothetical protein -
MQC90_RS14130 (2676394) 2676394..2676831 - 438 WP_003229927.1 hypothetical protein -
MQC90_RS14135 (2676844) 2676844..2677347 - 504 WP_003246050.1 HK97 gp10 family phage protein -
MQC90_RS14140 (2677344) 2677344..2677706 - 363 WP_003229925.1 YqbH/XkdH family protein -
MQC90_RS14145 (2677703) 2677703..2678098 - 396 WP_004398566.1 DUF3199 family protein -
MQC90_RS14150 (2678102) 2678102..2678413 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2632760..2694460 61700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T239801 WP_004398662.1 NZ_CP094361:2673457-2673636 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T239801 NZ_LS483324:c2181459-2181250 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 223 bp

>AT239801 NZ_CP094361:c2673782-2673560 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References