Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 3496407..3496732 Replicon chromosome
Accession NZ_CP064095
Organism Bacillus subtilis strain N1303-2Ay

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag IRJ27_RS17975 Protein ID WP_004398662.1
Coordinates 3496553..3496732 (-) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 3496407..3496629 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ27_RS17930 (3491776) 3491776..3492087 + 312 WP_003229923.1 YqbF domain-containing protein -
IRJ27_RS17935 (3492091) 3492091..3492486 + 396 WP_004398566.1 DUF3199 family protein -
IRJ27_RS17940 (3492483) 3492483..3492845 + 363 WP_003229925.1 YqbH/XkdH family protein -
IRJ27_RS17945 (3492842) 3492842..3493345 + 504 WP_003246050.1 HK97 gp10 family phage protein -
IRJ27_RS17950 (3493358) 3493358..3493795 + 438 WP_003229927.1 hypothetical protein -
IRJ27_RS17955 (3493792) 3493792..3493983 + 192 WP_010886574.1 hypothetical protein -
IRJ27_RS17960 (3493984) 3493984..3495384 + 1401 WP_003229929.1 phage tail sheath family protein -
IRJ27_RS17965 (3495387) 3495387..3495830 + 444 WP_003229930.1 phage tail tube protein -
IRJ27_RS17970 (3496084) 3496084..3496173 - 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
- (3496407) 3496407..3496629 + 223 NuclAT_0 - Antitoxin
- (3496407) 3496407..3496629 + 223 NuclAT_0 - Antitoxin
- (3496407) 3496407..3496629 + 223 NuclAT_0 - Antitoxin
- (3496407) 3496407..3496629 + 223 NuclAT_0 - Antitoxin
IRJ27_RS17975 (3496553) 3496553..3496732 - 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
IRJ27_RS17980 (3496878) 3496878..3497327 + 450 WP_003229933.1 phage portal protein -
IRJ27_RS17985 (3497369) 3497369..3497506 + 138 WP_003229934.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3475729..3537429 61700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T180078 WP_004398662.1 NZ_CP064095:c3496732-3496553 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T180078 NZ_CP085061:c148855-148550 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 223 bp

>AT180078 NZ_CP064095:3496407-3496629 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References