Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2678240..2678565 Replicon chromosome
Accession NZ_CP011115
Organism Bacillus subtilis KCTC 1028 = ATCC 6051a strain KCTC 1028

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag O7A_RS14185 Protein ID WP_004398662.1
Coordinates 2678240..2678419 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2678343..2678565 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O7A_RS22880 2677466..2677603 - 138 WP_003229934.1 hypothetical protein -
O7A_RS14180 2677645..2678094 - 450 WP_003229933.1 phage portal protein -
O7A_RS14185 2678240..2678419 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 2678343..2678565 - 223 NuclAT_0 - Antitoxin
- 2678343..2678565 - 223 NuclAT_0 - Antitoxin
- 2678343..2678565 - 223 NuclAT_0 - Antitoxin
- 2678343..2678565 - 223 NuclAT_0 - Antitoxin
O7A_RS23470 2678799..2678888 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
O7A_RS14190 2679142..2679585 - 444 WP_003229930.1 phage tail tube protein -
O7A_RS14195 2679588..2680988 - 1401 WP_003229929.1 phage tail sheath family protein -
O7A_RS14200 2680989..2681180 - 192 WP_010886574.1 hypothetical protein -
O7A_RS14205 2681177..2681614 - 438 WP_003229927.1 hypothetical protein -
O7A_RS14210 2681627..2682130 - 504 WP_003246050.1 HK97 gp10 family phage protein -
O7A_RS14215 2682127..2682489 - 363 WP_003229925.1 YqbH/XkdH family protein -
O7A_RS14220 2682486..2682881 - 396 WP_004398566.1 DUF3199 family protein -
O7A_RS14225 2682885..2683196 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2645490..2699243 53753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T53446 WP_004398662.1 NZ_CP011115:2678240-2678419 [Bacillus subtilis KCTC 1028 = ATCC 6051a]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T53446 NZ_CP011115:2678240-2678419 [Bacillus subtilis KCTC 1028 = ATCC 6051a]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT53446 NZ_CP011115:c2678565-2678343 [Bacillus subtilis KCTC 1028 = ATCC 6051a]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References