Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2644072..2644397 Replicon chromosome
Accession NZ_AP024626
Organism Bacillus subtilis strain BEST3125

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag K6K02_RS13845 Protein ID WP_004398662.1
Coordinates 2644072..2644251 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2644175..2644397 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K02_RS13835 (2643298) 2643298..2643435 - 138 WP_003229934.1 hypothetical protein -
K6K02_RS13840 (2643477) 2643477..2643926 - 450 WP_003229933.1 phage portal protein -
K6K02_RS13845 (2644072) 2644072..2644251 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- (2644175) 2644175..2644397 - 223 NuclAT_0 - Antitoxin
- (2644175) 2644175..2644397 - 223 NuclAT_0 - Antitoxin
- (2644175) 2644175..2644397 - 223 NuclAT_0 - Antitoxin
- (2644175) 2644175..2644397 - 223 NuclAT_0 - Antitoxin
K6K02_RS13850 (2644631) 2644631..2644720 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
K6K02_RS13855 (2644974) 2644974..2645417 - 444 WP_003229930.1 phage tail tube protein -
K6K02_RS13860 (2645420) 2645420..2646820 - 1401 WP_003229929.1 phage tail sheath family protein -
K6K02_RS13865 (2646821) 2646821..2647012 - 192 WP_010886574.1 hypothetical protein -
K6K02_RS13870 (2647009) 2647009..2647446 - 438 WP_003229927.1 hypothetical protein -
K6K02_RS13875 (2647459) 2647459..2647962 - 504 WP_003246050.1 HK97 gp10 family phage protein -
K6K02_RS13880 (2647959) 2647959..2648321 - 363 WP_003229925.1 YqbH/XkdH family protein -
K6K02_RS13885 (2648318) 2648318..2648713 - 396 WP_004398566.1 DUF3199 family protein -
K6K02_RS13890 (2648717) 2648717..2649028 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2613585..2665075 51490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T39095 WP_004398662.1 NZ_AP024626:2644072-2644251 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T39095 NZ_AP024626:2644072-2644251 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT39095 NZ_AP024626:c2644397-2644175 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References