Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2651006..2651331 Replicon chromosome
Accession NZ_CP007800
Organism Bacillus subtilis subsp. subtilis str. JH642 substr. AG174 strain JH642

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag BSUA_RS14125 Protein ID WP_004398662.1
Coordinates 2651006..2651185 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2651109..2651331 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSUA_RS14115 2650232..2650369 - 138 WP_003229934.1 hypothetical protein -
BSUA_RS14120 2650411..2650860 - 450 WP_003229933.1 phage portal protein -
BSUA_RS14125 2651006..2651185 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 2651109..2651331 - 223 NuclAT_0 - Antitoxin
- 2651109..2651331 - 223 NuclAT_0 - Antitoxin
- 2651109..2651331 - 223 NuclAT_0 - Antitoxin
- 2651109..2651331 - 223 NuclAT_0 - Antitoxin
BSUA_RS22850 2651565..2651654 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
BSUA_RS14130 2651908..2652351 - 444 WP_003229930.1 phage tail tube protein -
BSUA_RS14135 2652354..2653754 - 1401 WP_003229929.1 phage tail sheath family protein -
BSUA_RS14140 2653755..2653946 - 192 WP_010886574.1 hypothetical protein -
BSUA_RS14145 2653943..2654380 - 438 WP_003229927.1 hypothetical protein -
BSUA_RS14150 2654393..2654896 - 504 WP_003246050.1 HK97 gp10 family phage protein -
BSUA_RS14155 2654893..2655255 - 363 WP_003229925.1 YqbH/XkdH family protein -
BSUA_RS14160 2655252..2655647 - 396 WP_004398566.1 DUF3199 family protein -
BSUA_RS14165 2655651..2655962 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2625759..2675870 50111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T47077 WP_004398662.1 NZ_CP007800:2651006-2651185 [Bacillus subtilis subsp. subtilis str. JH642 substr. AG174]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T47077 NZ_CP007800:2651006-2651185 [Bacillus subtilis subsp. subtilis str. JH642 substr. AG174]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT47077 NZ_CP007800:c2651331-2651109 [Bacillus subtilis subsp. subtilis str. JH642 substr. AG174]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A164X333


Antitoxin

Download structure file

References