Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2702351..2702676 Replicon chromosome
Accession NZ_CP051860
Organism Bacillus subtilis subsp. subtilis str. 168

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag HIR76_RS14130 Protein ID WP_004398662.1
Coordinates 2702351..2702530 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2702454..2702676 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIR76_RS14120 2701577..2701714 - 138 WP_003229934.1 hypothetical protein -
HIR76_RS14125 2701756..2702205 - 450 WP_003229933.1 phage portal protein -
HIR76_RS14130 2702351..2702530 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 2702454..2702676 - 223 NuclAT_0 - Antitoxin
- 2702454..2702676 - 223 NuclAT_0 - Antitoxin
- 2702454..2702676 - 223 NuclAT_0 - Antitoxin
- 2702454..2702676 - 223 NuclAT_0 - Antitoxin
HIR76_RS14135 2702910..2702999 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
HIR76_RS14140 2703253..2703696 - 444 WP_003229930.1 phage tail tube protein -
HIR76_RS14145 2703699..2705099 - 1401 WP_003229929.1 phage tail sheath family protein -
HIR76_RS14150 2705100..2705291 - 192 WP_010886574.1 hypothetical protein -
HIR76_RS14155 2705288..2705725 - 438 WP_003229927.1 hypothetical protein -
HIR76_RS14160 2705738..2706241 - 504 WP_003246050.1 HK97 gp10 family phage protein -
HIR76_RS14165 2706238..2706600 - 363 WP_003229925.1 YqbH/XkdH family protein -
HIR76_RS14170 2706597..2706992 - 396 WP_004398566.1 DUF3199 family protein -
HIR76_RS14175 2706996..2707307 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2671864..2727215 55351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T155372 WP_004398662.1 NZ_CP051860:2702351-2702530 [Bacillus subtilis subsp. subtilis str. 168]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T155372 NZ_CP068799:4279367-4279519 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 223 bp

>AT155372 NZ_CP051860:c2702676-2702454 [Bacillus subtilis subsp. subtilis str. 168]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References