Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2484391..2484716 Replicon chromosome
Accession NZ_CP005997
Organism Bacillus subtilis TO-A

Toxin (Protein)


Gene name txpA Uniprot ID P54373
Locus tag M036_RS12895 Protein ID WP_004398662.1
Coordinates 2484391..2484570 (+) Length 60 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2484494..2484716 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M036_RS12885 2483617..2483754 - 138 WP_003229934.1 hypothetical protein -
M036_RS12890 2483796..2484245 - 450 WP_003229933.1 phage portal protein -
M036_RS12895 2484391..2484570 + 180 WP_004398662.1 type I toxin-antitoxin system toxin TxpA Toxin
- 2484494..2484716 - 223 NuclAT_0 - Antitoxin
- 2484494..2484716 - 223 NuclAT_0 - Antitoxin
- 2484494..2484716 - 223 NuclAT_0 - Antitoxin
- 2484494..2484716 - 223 NuclAT_0 - Antitoxin
M036_RS21720 2484950..2485039 + 90 WP_075058862.1 type I toxin-antitoxin system toxin BsrH -
M036_RS12900 2485293..2485736 - 444 WP_003229930.1 phage tail tube protein -
M036_RS12905 2485739..2487139 - 1401 WP_003229929.1 phage tail sheath family protein -
M036_RS12910 2487140..2487331 - 192 WP_010886574.1 hypothetical protein -
M036_RS12915 2487328..2487765 - 438 WP_003229927.1 hypothetical protein -
M036_RS12920 2487778..2488281 - 504 WP_003246050.1 HK97 gp10 family phage protein -
M036_RS12925 2488278..2488640 - 363 WP_003229925.1 YqbH/XkdH family protein -
M036_RS12930 2488637..2489032 - 396 WP_004398566.1 DUF3199 family protein -
M036_RS12935 2489036..2489347 - 312 WP_003229923.1 YqbF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2453904..2505394 51490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6739.19 Da        Isoelectric Point: 8.0370

>T45159 WP_004398662.1 NZ_CP005997:2484391-2484570 [Bacillus subtilis TO-A]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Download         Length: 180 bp

>T45159 NZ_CP005997:2484391-2484570 [Bacillus subtilis TO-A]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 223 bp

>AT45159 NZ_CP005997:c2484716-2484494 [Bacillus subtilis TO-A]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164X333

Antitoxin

Download structure file

References